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A comparison of two approaches for intraoperative levosimendan administration in cardiac surgical patients with severe left ventricle dysfunction


DOI: http://dx.doi.org/10.18821/0201-7563-2016-61-5-334-338

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Abstract

Background. It is proved that levosimendan administration improves overall outcome and reduces mortality in high risk cardiac patients. However, up to now there is no optimal scheme of its use in intraoperative settings. The aim. To compare two approaches oflevosimendan administration in patients with left ventricle ejection fraction less than 35% who underwent cardiac surgery. Materials and methods. After approval by the local ethics Committee, 40 patients older than 18 years with severe preoperative left ventricular dysfunction (left ventricle ejection fraction less than 35%), who were planned for cardiac surgery operation with cardiopulmonary bypass and cardioplegia were randomly assigned to two groups of 20 patients each. In group 1 (n=20) infusion of levosimendan started intraoperatively after induction of anesthesia, a loading dose of 6 mg/kg with subsequent injection of a dose of 0.1 μg/kg/min for 24 hours. In group 2 (n=20) bolus of levosimendan 24 μg/kg was injected 15 min before aortic clamping. Anesthesia and methods of cardiopulmonary bypass in the groups did not differ. Results. We got the favorable clinical results in a group of “full” levosimendan dose (12.5 mg as a daily infusion with an initial bolus of 6 mg/kg just after the induction of anesthesia) in terms of reduction of the total dose of sympathomimetics and postoperative troponin T level in comparison with the group where levosimendan was administered as a single bolus (24 mg/kg) 15 minutes prior to aortic clamping. Conclusion. Based on these data it can be assumed that the use of prolonged infusion of levosimendan in a dosage of 12.5 mg is preferable to a single bolus 24 μg/kg.


Для цитирования: Pasyuga V.V., Belov S.I., Yusupova E.S., Adzhigaliev R.R., Berezhnoy S.A., Panov O.S., Tarasov D.G., Yavorovsky A.G. A comparison of two approaches for intraoperative levosimendan administration in cardiac surgical patients with severe left ventricle dysfunction. Anesteziologiya i reanimatologiya (Russian journal of Anаеsthesiology and Reanimatology) 2016; 61(5): 334-338. (In Russ.). DOI: http://dx.doi.org/10.18821/0201-7563-2016-61-5-334-338

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ISSN: 0201-7563 (Print)
ISSN: (Online)