POSTOPERATIVE CONTINUOUS EPIDURAL ANALGESIA FOR SPINAL SURGERY PART II. THE EFFECT OF POSTOPERATIVE CONTINUOUS EPIDURAL ANALGESIA ON THE SYSTEMIC INFLAMMATORY STRESS RESPONSE
Material and metods. A prospective randomized trial included 139 patients with spinal pathology who were operated. We studied the efficacy pain relief and dynamics of the inflammatory stress response during postoperative continuous epidural analgesia in comparison the traditional methods of postoperative analgesia. In comparative groups blood samples were taken, evaluated the efficacy of pain relief and character of postoperative complications. Systemic hemodynamic parameters were also assessed. We determined the plasma concentration of the major inflammatory markers (C-reactive protein, cytokines - interleukin-6 and interleukin-2) in the blood samples taken at the study stages. Results. In patients with postoperative continuous epidural analgesia a decrease in postoperative nausea and vomiting, a decrease in the number of inflammatory complications and decrease in the incidence of urinary retention were noted. Dynamics plasma concentration of C-reactive protein, interleukin-6 and interleukin-2 showed a more balanced immune response in postoperative for patients with continuous epidural analgesia compared with the control group. Screening markers of inflammation and interleukins allows to objectify the effect of pain therapy and to identify the inflammatory and autoimmune processes.
About the authorsSolenkova A.V.
Lubnin Andrey Yu
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