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CORRECTION OF ARTERIAL HYPERTENSION DURING THE POSTOPERATIVE PERIOD IN NEUROSURGICAL PATIENTS


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Abstract

Ntroduction. Arterial hypertension is one of the leading causes of intracranial complications during the early postoperative period after neurosurgical interventions. It predisposes to development of brain oedema or even intracranial hematomas. This is why correction and stabilization of arterial pressure during the early postoperative period after neurosurgery remains one of the major aims in the management of this patient population. The goal: in this open-label study, we compared the monotherapeutic efficacy of different antihypertensive drugs in neurosurgical patients. Material and methods. Sixty patients with arterial hypertension in the early postoperative period after craniotomy were prospectively randomized to receive different antihypertensive medications. The effectiveness of three drugs: urapidil, klonidin enalapril was compared. Results. Mean time for bringing the arterial pressure below the 160 mm Hg threshold for urapidil was 9,25 minutes, 13,5 minutes for klonidin and 15,5 minutes for enalapril groups. The incidence of therapeutic failure was 5% for urapidil, 10% for klonidin and 40% for enalapril. Conclusion. Urapidil showed the best results for controlling arterial hypertension in early postoperative patients undergoing neurosurgery.


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