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NEUROENDOCRINE PANCREATIC CANCER: THE RESULTS OF SURGICAL TREATMENT


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Abstract

Objective. To evaluate the immediate and remote results of surgical treatment of patients with neuroendocrine tumors of the pancreas. Material and methods. The study included 121 patients with neuroendocrine tumors of the pancreas subjected to surgical treatment. The options of surgery were the following: distal pancreatectomy, in most cases in the form of a distal subtotal resection of the pancreas with splenectomy - 60 (49.6%) patients; gastropancreatoduodenal resection - 54 (44.6%); pancreatectomy - 2 (1.7%); the median resection of the pancreas - 1 (0.8%); enucleation of the tumor - 3 (2.5%). Multivariate retrospective and prospective analysis of large clinical material was carried out, adequate tactics of surgical treatment of neuroendocrine tumors of the pancreas was determined, depending on the extent of the process and the results of morphological studies, especially in relation to high grade tumors. Results. The immediate and remote results of surgical treatment were analyzed. The overall survival rates after surgical treatment of pancreatic neuroendocrine tumors were: 1-year - 91±3%, 3-year - 83±4%, 5-year - 79±4%, 10-year - 66±7%. The median survival was 161 months. Disease-free survival: 1-year - 85 ±4%, 3-year - 76± 5%, 5-year - 72± 5%, 10-year - 53 ± 8%. The median relapse-free survival rate was 137 months. Conclusion. Long-term results of surgical treatment of patients with pancreatic neuroendocrine tumors obtained in our study indicate a more favourable prognosis for these patients compared with pancreatic tumors of other histogenesis. These data allow the greater use the surgical method in such patients.


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