NEUROHUMORAL REGULATION OF LEFT VENTRICULAR REMODELING IN POSTINFARCTION ANEURYSM

One of the complications of transmural myocardial infarction is the development of left ventricular aneurysm. The process of remodeling consisting of progressive dilatation, left ventricular deconfiguration, systolic and diastolic dysfunction is one of the main causes of congestive heart failure development. In this literature review the pathophysiological foundations, humoral systems of regulation of left ventriclular postinfarction remodeling and features of the vegetative innervation of postinfarction myocardium are considered. A clear understanding of the pathogenesis of the pathological process in the cardiac muscle in each case of myocardial infarction allows to develope an individual approach to choosing a treatment strategy.

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