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The levels of specific autoantibodies and risks for the formation of pathological processes in conditions of inhalation exposure to chemicals


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Abstract

The exposure of atmospheric pollutants on the organism may be a precondition for the development ofpathological processes in organs and system to which they have tropicity. The change in the levels of specific autoantibodies occur long before the clinical manifestation of the disease. The aim of the study was the investigation of relationships between the levels of specific autoantibodies and risks of the formation of pathological processes of organs and systems in conditions of the inhalation exposure to chemicals. There was made an assessment of levels of the air pollution and indoor air in the industrial centers of Eastern Siberia. There were calculated indices of danger from the inhalation exposure of chemical compounds and the risks for the development of the pathology of organs and systems. There was studied the relative content of specific autoantibodies to the organs and systems that are at high risk of the development ofpathological processes. The highest overall risks for the development of respiratory diseases, immune system and cardiovascular system were established in schoolchildren residing in areas of high and medium levels of air pollution. In general, the identified changes in the content of specific autoantibodies characterizing the state of the major organs and systems of children residing in areas of high risk for the development ofpathological processes associated with the content of chemical compounds in the air, cannot be properly interpreted as the realized risk of environmental impacts and require further study.


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