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Determination of silver in tissues and organs of broiler chickens after oral and aerosol administration of an aqueous dispersion of silver nanoparticles


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Abstract

An aqueous dispersions of silver nanoparticles (10 ppm, 50 ppm, 300 ppm) stabilized with 100-600 ppm of chloride benzyldimethyl[3-(myristoylamino)propyl]ammonium monohydrate (miramistin) have been used in the experiment. These compositions were registered in Russia in 2014 as a veterinary drug under the brand name Argumistin®. One of the indications for oral and aerosol administration of Argumistin® is respiratory and gastrointestinal infections of broiler chickens. Miramistin-stabilized silver nanoparticles administered at a dose of 0.32 pg of silver per 1 kg of body weight per day almost completely retained in the body of broilers, while the increasing of the administered dose up to 1.92 pg of silver per 1 kg of body weight per day reduced the retention rate up to 30%. With taking into account WHO recommendations and Russian regulations the oral administration of 10 ppm of silver at above mentioned doses can be concluded to fail to cause accumulation of silver in the tissue and organs of broiler chickens in concentrations dangerous for humans.


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