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PHENOMICS. ETIOLOGY OF HUMAN ORGANISM FUNCTIONAL STATES UNDER THE EFFECT OF ENVIRONMENTAL FACTORS


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Abstract

The article based on the analysis and synthesis of scientific works regarding the theory of adaptation offers the detailed description of the development of functional responses of the human organism under the impact of environmental factors. Three types of responses are considered: nonspecific reaction of human organism, specific response of the human organism and response of the human organism to specificity of a factor. The article is focused on form for the rationale for specific response of the human organism. It is due to the fact that in scientific literature in the capacity of such response it is often assumed the response of the human organism to specificity of an operating environmental factor. Development of responses is shown on the basis of a phenome - phenotypical model of the human organism. The model is described by norms of the response of the main systems of human organism and the scheme of an orientation of interaction of these systems among themselves. On its basis the logic of a pathogenesis of noninfectious diseases is considered. The development of both nonspecific, and specific responses of the human organism including responses to the specificity of a factor is show to occur according to the universal stereotypic scheme presented in the article. The purpose and the result of this work is the development of the common theory of adaptation of human organism to the impact of environmental factors. Knowledge of mechanisms of the development of changes of the functional condition of systems of the human organism in response to the risk factor opens a way to the creation of the mathematical model of the process of the prediction of functional violations promoting the development of noninfectious diseases and other adverse deviations from the state of health. Monitoring of the functional condition of human organism and knowledge of relationships of cause and effect of the functional changes will allow doctors, trainers and teachers to avoid the negative consequences in their practical activities


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