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ASSESSMENT OF INFLAMMATION MEDIATORS UNDER EXPOSURE TO THE VIBRATION IN EMPLOYEES IN DEPENDENCE ON PRONOUNCEMENT OF THE PATHOLOGICAL PROCESS


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Abstract

The aim of the study was to identify changes in concentrations of pro- and anti-inflammatory cytokines, depending on the severity of health disorders in workers. Under observation there were employees working in conditions of the occupational vibration (experienced workers with a long-term working period without signs of the disorders of health, patients with the vibration-induced disease (VID) and patients with VID at the remote period). There was established the aggravation of the imbalance of pro- and anti-inflammatory cytokines with an increase in the severity of the pathological process. There were identified unidirectional changes of indices in patients with various degree of the severity of the health disorder characterized by a decrease in serum concentrations of TNF-α, IFN-γ, IL-4, IL-10. This is apparently due to the inhibition of the functional activity as T helper type 1 and T helper type 2. The determination of mediators of the immune response in employees of vibration hazard occupations may serve as a marker for the early screening assessment of health problems and the severity of the clinical course of the VID.


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