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ON THE ROLE OF THE THIOLDISULPHYDE SYSTEM IN PROTECTION THE HUMAN BODY FROM AEROSOL AIR POLLUTION


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Abstract

In this paper results of research of quantitative distribution and qualitative characteristics of microdispersed particles of atmospheric air in the city of Vladivostok are presented. The chronic impact of aerosols of a microsize range on inhabitants of the urbanized territory led to the development of a condition of an oxidative stress giving rise in the increase of the level of oxidative damages of cellular macromolecules and the expansion in the number of cells with the lowered power status in comparison with residents of the favorable area. The induction of oxidative processes caused the enlargement in the content of key antioxidant enzymes (thireodoxin, glutathione, superoxide dismutase) and the gain of antioxidant activity in general. The main role in reparation of proteins and DNA in the oxidizing influence of microdispersed particles belongs to thioredoxin system due to restoration of thiol-disulfide communications and restoration of reparating enzymes. Thiol-disulfide-depended antioxidant processes make an essential contribution to the protection of an organism, preventing the development of the oxidative stress and the cell apoptosis. Long-term stress - induced influence of microdispersed particles can lead to exhaustion of adaptation and reparation opportunities of an organism and to promote еру development of pathology.


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