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PECULIARITIES OF IMMUNOREGULATORY INDICES IN CHILDREN LIVING IN THE CONDITIONS OF AEROGENOUS EXPOSITION BY ALUMINUM


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Abstract

In the group of children population living under conditions of aerogenic exposure to aluminum, the average concentration of aluminum in urine was found to be significantly (p <0.05), by 5.5 times higher than the reference values and by 4.5 times more than the similar index in the comparison group. The estimation of the parameters of the dependence “average concentration of the substance in the ambient air - concentration of the substance in the urine” made it possible to obtain adequate (F ≥ 3.96, p ≤ 0.05) and biologically plausible models of the dependence of the concentration of aluminum in urine on its average concentration upon it entering from the atmospheric air. The significant excess of the total and specific sensitization to aluminum in the main group and comparison group was found to be 1.4 and 1.5 times correspondingly. The level of specific IgG to aluminum in 44% of the children of the examined group was significantly higher than the reference level and similar indices of the comparison group (p <0.05). A significant decrease in the serotonin content in the observation group was established to be by 1.9 times (p <0.05) lower than in the control group. The analysis of cause-effect relationships made it possible to verify a decrease in the blood concentration of serotonin with an increase in the urine content of aluminum (R2 = 0.20, p <0.05). There were detected peculiarities of immunoregulatory disorders in children living under conditions of aerogenic exposure to aluminum in terms of a significant decrease in phagocytic activity in relation to the norm, suppression of CD95+, Bax and activation of CD127-, indicating to a dysregulation of the processes of the programmed cell death, which, under conditions of chronic hapten exposure lead to the formation of immune depression and further to the development of immunodeficient and autoimmune conditions. The developed system of immunological indices and the tendency in their changes are recommended for monitoring of early immunoregulatory disorders associated with exposure to aluminum.


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