THE STATE OF THE CENTRAL AND PERIPHERAL CONDUCTIVE STRUCTURES OF WORKERS PRODUCING POLYVINYLCHLORIDE IN DEPENDENCE ON THE TOXIC DOSE LOAD
Introduction. Hygienic studies in the production of polyvinyl chloride showed vinyl chloride to be the main adverse factor affecting workers. Many years of clinical investigations of employees of “East-Siberian Institute of Medical and Ecological Research” proved the formation of the initial manifestations of chronic intoxication with vinyl chloride with the damage to the nervous system in a few years from the beginning of production in contact with the toxicant, the marked dependence of the risk of violations of workers health from exposure value toxic load (EVTL). Currently, the study of changes in neurological indices depending on the level of the toxic exposure load is very relevant. Based on the mentioned above, the aim of the study was to identify the characteristics of the state of the central and peripheral conductive structures in the intermediate workers of the production of vinyl chloride taking into account the toxic exposure of the load. Material and methods. A group of stair workers contacting with vinyl chloride was examined. There were observed 42 males of the mean age of 49.2±4.4 years, the average duration of the exposure to vinyl chloride was 18.1±5.6 years. Examined cases were distributed into two groups: 1 group included 31 workers with a moderate extent of EVTL, 2 group consisted of 11 persons with extremely high EVTL. The control group included 30 male employees, matched for the age without exposure to occupational harmful impacts. The concentration of vinyl chloride was determined in the blood samples of the observed patients, somatosensory evoked potentials were registered and stimulation electroneuromyography was performed according to the conventional method. Results. The study showed changes in individuals with a higher EVTL value. Changes in the functional state of neurons in the brain stem were revealed. At the periphery level, there were more noted more pronounced alterations in the functional state of the motor and the sensory axons of the cubital and tibial nerve. The established relationship between the EVTL value in exposed workers, and the pronouncement of the studied indices characterizing the state of the central the periphery, conductive structures, allows speaking about the dependence of the lattters on conditions existing in the production of polyvinyl chloride
About the authorsRusanova Dina V.
Mogilenkova L.A., Kiselev B.D., Krinitsyn N.V., Filippov V.L. The impact of vinyl chloride on the health of workers. Chemical safety of the Russian Federation in modern conditions. All-Russian scientific-practical conference. [Vserossiyskaya nauchno-prakticheskaya konferentsiya]. SPb; 2010: 285-288. (in Russian)
Bolognesi C., Bruzzone M., Ceppi M., Kirsch-Volders M. The lymphocyte cytokinesis block micronucleus test in human populations occupationally exposed to vinyl chloride: А systematic review and meta-analysis. Mutation Research. 2017; 774: 1-11.
Lotti M. Do occupational exposures to vinyl chloride cause hepatocellular carcinoma and cirrhosis. Liver International. 2017; 37(5): 630-633.
Grishin A.N., Gutkovich S.A. Properties of concentrated solutions of polyvinchloride Plasticheskiye massy. 2010; 2: 29-32. (in Russian)
Flid M.R., Treger Yu.A. Vinylchloride: chemistry and technology. M.: Calvis. 2008. 584 р. (in Russian)
Malysheva A.G., Rakhmanin Yu.A. Physico-chemical studies and control methods of substances in environmental hygiene. St. Petersburg: Professional; 2014. (in Russian)
Rakhmanin Yu. A., Mikhailova R. I. Environment and health: preventive medicine priorities. Gigiena i sanitariya. 2014; 5: 5-11. (in Russian)
Zhurba O.M., Shayakhmetov S.F., Alekseenko A.N., Merinov A.V., Dorogova V.B. Study of the biomarker of exposure of organochlorine compounds in workers production of vinyl chloride and polyvinyl chloride. Gigiena i sanitariya. 2018; 97 (2): 160-4. (in Russian)
Kapustina E.A., Rusanova D.V. EMG manifestations in experimental intoxication with vinylchloride. Аcta biomedica scientifica. 2007; 6: 78-80. (in Russian)
Shayakhmetov S.F., Dyakovitch M.P., Meshchakova N.M. Assessment of occupational risk of health disorders in chemical industry workers. Meditsina truda i promyishlennaya ekologiya. 2008; 8: 27-33. (in Russian)
Fazeul H. Molecular modeling analysis of the metabolism of vinyl chloride. J. of Pharmacology and Toxicology. 2006; 4(1): 299-316.
Katamanova E.V., Dyakovich M.P., Kudaeva I.V., Shevchenko O.I., Eshchina I.M., Rukavishnikov V.S. etc. Сlinical аnd neurophysiological features of health disorders of workers depending on the exposure load with vinyl chloride. Hygiene and sanitation. 2016; 12: 1167-71. (in Russian)
Kudaeva I.V., Budarina L.A., Masnavieva L.B. Patterns of violations of biochemical processes under the influence of neurotoxic substances of different nature. Meditsina truda i promyishlennaya ekologiya. 2008; 8: 7-11. (in Russian)
Kudaeva I.V., Budarina L.A. Indicators of protein metabolism in persons exposed to vinyl chloride. Clinical laboratory diagnostics. 2012; 9:91-6. (in Russian)
Kolesov V.G. Electroneuromyography in the diagnosis of vibration disease. Meditsina truda i promyishlennaya ekologiya. 2008; 8: 7-11. (in Russian)
Benaim J.L; Amar O; Alliez A; Bertrand B, Annales De Chirurgie Plastique Et Esthetique. The interest of electroneuromyography in peripheral facial palsy. Ann Chir Plast Esthet, 2015; 60 (5): 374-6.
De Jesus Filho A.G., do Nascimento B.F., Amorim Mde C., Naus R.A., Loures Ede A., Moratelli L. Comparative study between physical examination, electroneuromyography and ultrasonography in diagnosing carpal tunnel syndrome. Rev Bras Ortop. 2014; 49(5): 446-51.
Rusanova D.V., Lakhman O.L. Changes in the state of central and peripheral conducting systems among trained workers in chemical industries. Аcta biomedica scientifica. 2008; 5: 19-23. (in Russian)
Brandt-Rauf P.W., Li Y., Long C., Monaco R. Plastics and carcinogenesis: The example of vinyl chloride. Journal of Carcinogenesis. 2012; 11: 5-8.
Guide to a hygienic assessment of factors of a working environment and labour process. Criteria and classification of working conditions: R. 2.2.2006-05. Moscow; 2005. (in Russian)
Nikolaev S.G. Workshop on clinical electroneuromyography. [Praktikum po klinicheskoy elektroneyromiografii]. Ivanovo: IGMA; 2003. (in Russian)
Meshchyakova N.M, Dyakovitch M.P., Shayakhmetov S.F., Dyakovich O.А., Bogie.Assessment of the risk of health and quality of life of workers in the modern production of polyvinyl chloride. Meditsina truda i promyishlennaya ekologiya. 2014; 4: 24-29. (in Russian)
Sherman M. Vinyl chloride and the liver. Journal of Hepatology. 2009; 51(6): 1074-81.
Wang X.X., Xiao J.W., Meng H.L., Cui T. et al. Effect of vinyl chloride on reproductive and endocrine system of male rats. Chinese journal of industrial hygiene and occupational disease. 2010; 28 (7): 517-20
Mogilenkova L.A., Effects of vinyl chloride on the health of workers in the workplace. Medline.ru. Rossiyskiy biomeditsinskiy zhurnal. 2011; 2: 558-71. (in Russian)
Sosedova L.M., Golubev S.S., Titov E.A. Pathomorphological aspects of the effect of vinyl chloride on the brain tissue of white rats in the dynamics of the post-contact period. Toksikologicheskiy vestnik. 2009; 5: 23-6. (in Russian)
Sosedova L. M., Kapustina E. A., Titov E. A. Morpho-functional disorders in rats exposed to Lice in a long period of intoxication. Meditsina truda i promyishlennaya ekologiya. 2008; 1: 24-29. (in Russian)
Bodienkova G.M., Alekseev R.Yu. The state of functional systems of the organism working in the production of vinyl chloride (review). XXI vek. Tekhnosfernaya bezopasnost. 2016; 1: 82-7. (in Russian)
Mutlu E., Collins L.B., Stout M.D., Upton P.B. et al. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced - DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. Chemical research of toxicology. 2010. 23(9): 1485-91.
Kondrashov V.A. The importance of сlanputi chemicals entering the body and prevention of perch travel. SPb.: ELBI-SPb; 2014. 288. (in Russian)
- Refbacks are not listed
Контент доступен под лицензией Creative Commons Attribution 3.0 License.