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Introduction. Laboratory practice is characterized by an increased hardness of the work process. In the research presented, a complex comparative assessment of the working conditions and functional condition of the employees of the laboratory center “Center for Hygiene and Epidemiology in the Voronezh Region” was carried out, in which a laboratory information system (LIS) is planned to be introduced into the practice. The assessment of the conditions of the labor process and the functional state of the employees was also carried out in the testing laboratory of the Center for Hygiene and Epidemiology in the Tambov Region, where the LIS software operates in the regular mode. Material and methods. The study was conducted on 170 specialists of testing laboratory centers. There are given data on the assessment of the hardness and intensity of the labor process of laboratories of different types of activity at workplaces of testing laboratory centers in the Voronezh and Tambov regions. There was performed a clinical examination of specialists of testing laboratory centers on the indications of the cardiovascular system: dynamics of the heart rate, systolic and diastolic blood pressure, minute blood volume during the working day. Results. Based on a comparative analysis of the results obtained, conclusions were drawn about the peculiarities of working conditions and performance indices of employees of testing laboratory centers in the dynamics of the working week. Differences in the formation of fatigue in the specialists of laboratories for hygienic and epidemiological profiles of activity among employees of a testing laboratory center, working without an information system introduced into the professional activity, have been observed in the second half of the working day, whereas those working with a laboratory information system the state of the body is correct from the physiological positions. Discussion. The class of labor conditions for specialists in testing laboratory centers, regardless of the profile of activity according to the severity of the work process, was identified as hard work of grade 1 (3.1), the class of working conditions for the intensity of the labor process as a hard work of grade 2 (3.2). Evaluation of the functional state of the body according to the cardiovascular system testifies to a noticeable fatigue in the second half of the working day among specialists working without software and information support. Conclusions. The data obtained as a result of the research made it possible to develop and offer a complex of preventive measures aimed at optimizing working conditions for the introduction into the professional work of personnel of testing laboratory centers. As a result, additions were made to the Instruction on labor protection of specialists of the Center for Hygiene and Epidemiology in the Voronezh Region.

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