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CORRELATION BETWEEN THE INDICES OF PRO - AND ANTIOXIDANT ACTIVITY IN WORKERS OF THE NORTHERN REGION WITH DIFFERENT LEVELS OF THE ANTHROPOGENIC LOAD


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Abstract

The biosubstrates of 170 adults of the Khanty-Mansiysk Autonomous Okrug were studied: 88 donors and 82 drivers and workers of the gas station. The average age amounted to 31.5 ± 7.4 years. Using commercial kits in the blood, the pro-oxidant (lipid hydroperoxide, Gpl, TBA-active products,TBA-AP) and antioxidant (total antioxidant activity, OAA, thiol-TC) system were determined. In hair, the concentration of toxic chemical elements (Pb, Cd), and also Se, Zn, Ca, possessing antioxidant activity was determined by the methods of AEM-ICP and MS-ICP. A significant excess of LPO values in the blood and toxic chemical elements in the hair was observed against the background of a decrease in the activity of antioxidant protection system indices in the group of drivers and workers at the gas station (p <0.001-0.026). The statistically significant direct relationships between Se, Zn, Ca on the one hand and OAA, TC, on the other (p = 0.0005-0.043) and reverse with Gpl and TBA-AP (p = 0.007-0.038) on the background of direct correlation Pb, Cd with Gpl, TBA-AP (p = 0.007-0.018) and reverse with OAA, TS, Se, Zn, Ca (p = 0.0005-0.020). This indicates the possibility of correction of the reserves of the antioxidant system with the help of vitamin-mineral complexes containing these micronutrients and enriched food products.


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