IMMUNOLOGICAL INDICES IN WORKERS OF VARIOUS LIVESTOCK PRODUCTIONS
Introduction. The working conditions of livestock workers do not exclude the negative impact of the harmful biological factor of the work environment. Against the background of impaired immune homeostasis, the presence of saprophytic microorganisms in the working area air can contribute to the development of inflammatory pathology. The dynamic monitoring of the state of the immune system is needed due to the choice of tests in the conditions of health examinations of livestock workers. Material and methods. Working conditions, the state of health and the immune system of various livestock workers have been studied; analysis of the microbiological contamination of the work environment air has been conducted; patient groups according to the level of microbiological risk have been formed. Results. The hygienic studies conducted indicate industrial noise; aerosols in the form of a dust of plant and animal origin on the basis of grain; certain hazardous chemicals; the microclimate of production facilities, as well as the burden of labor to predominate in the livestock enterprises. In the work environment air, increased content of opportunistic microorganisms (pathogens of opportunistic infections) has been detected. Different modal abnormalities of immune status indices in response to microbial load have been revealed. The relationship between the quantitative characteristic of the total microbial load and the state of the immune system among workers in various livestock production has been established. Conclusion. The biological factor is a risk factor for the formation of different levels of both systemic and local disorders of the immune regulation. The potential risk for failure of compensatory-adaptive and adaptive mechanisms increases in proportion to the degree of total microbiological stress. Under conditions of increased microbiological risk, the dynamic control of workers’ immune system becomes important, which requires substantiation and development of adequate methodological approaches to the choice and use of diagnostic procedures and tests for mass health check-ups of livestock workers.
About the authorsMasyagutova Lyaylya M.
Popova A.Yu. Problems and trends in occupational morbidity among agricultural workers of the Russian Federation. Zdorov’e naseleniya i sreda obitaniya [Public Health and Life Environment]. 2016; 9: 4-9. (in Russian)
Gusev E.Yu., Chereshnev V.A. Systemic inflammation: theoretical and methodological approaches to the description of the general pathological process model. Part 4. Dynamics of the process. Patologicheskaya fiziologiya i eksperimental’naya terapiya [Pathological physiology and experimental therapy]. 2014; 4: 4-16. (in Russian)
Masyagutova L.M, Bakirov A.B., Rybakov I.D. Specific sensitization and local immunity of the oral cavity under the conditions of chronic aerogenic load. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics]. 2013; 4: 27-9. (in Russian)
Kosarev.V.V., Zhestkov A.V., Babanov S.A. Immunopathological features of occupational bronchitis. Meditsina truda i promyshlennaya ekologiya [Occupational health and industrial ecology]. 2012; 9: 22-7. (in Russian)
Bodienkova G.M., Rukavishnikov V.S. Disorders of the immunoreactivity as a marker of professional risk to the health of workers in the production of vinyl chloride. Gigiena i Sanitaria [Hygiene and Sanitation, Russian journal]. 2018; 97 (9): 840-3. (in Russian)
Cook-Mills J.M, Deem T.L. Active participation of endothelial cells in inflammation. J Leukoc Biol. 2005; 4: 487-95.
Hawley B., Schaeffer J., Poole J.A. Differential response of human nasal and bronchial epithelial cells upon exposure to size-fractionated dairy dust. J Toxicol Environ Health A. 2015; 78: 583-94.
Kumar S., Khodoun M., Kettleson E.M. Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation. Toxicology. 2014; 325: 42-51.
Charavaryamath C., Juneau V., Suri S.S., Janardhan K.S., Townsend H., Singh B. Role of Toll-like receptor 4 in lung inflammation following exposure to swine barn air. Exp Lung Res. 2008; 34: 19-35.
Robbe P., Spierenburg E.A., Draijer C. Shifted T-cell polarisation after agricultural dust exposure in mice and men. Thorax. 2014; 69: 630-7.
Wåhlén K., Fornander L., Olausson P. Protein profiles of nasal lavage fluid from individuals with work-related upper airway symptoms associated to moldy and damp buildings. Indoor Air. 2015; 25: 122-37.
Serefhanoglu K., Timurkaynak E., Can E. et al. Risk factors for candidemia with non-albicans Candida spp. in intensive care unit patients with end-stage renal disease on chronic hemo-dialysis. J Formos Med Assoc. 2012; 3: 325-32.
Masyagutova L.M., Bakirov A.B. Improving the system of hygienic monitoring in conditions of airborne contamination of the working area by opportunistic microorganisms. Meditsina truda i promyshlennaya ekologiya [Occupational Health and Industrial Ecology]. 2018; 3: 30-4. (in Russian)
Masyagutova L.M., Bakirov A.B., Simonova N.I., Gizatullina L.G. Laboratory substantiation of the phasing and volume of preventive measures when working in conditions of microbial air pollution of the working area. Klinicheskaya laboratornaya diagnostika [Clinical laboratory diagnostics]. 2018; 9: 584-7. (in Russian)
Masyagutova L.M., Bakirov A.B. Assessment of the health status of livestock workers. Obshchestvennoye zdorov’ye i zdravookhraneniye [Public Health and Health Care]. 2019; 2: 34-4. (in Russian)
Potapova A.I., ed. Clinical laboratory diagnosis of occupational diseases. Yaroslavl: Kantsler; 2013. 312 p. (in Russian)
Kolkhir P.V. Evidence-based allergology-immunology. Mоscow: Prakticheskaya meditsina; 2010. 528 p. (in Russian)
- Refbacks are not listed
Контент доступен под лицензией Creative Commons Attribution 3.0 License.