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Efficacy of induction therapy in patients with de novo diagnosed multiple myeloma depends on c-MYC gene expression at the debut of disease


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Abstract

The relationship between the type of antitumor response to induction therapy in patients with multiple myeloma (MM) and/or monoclonal gammopathy of undetermined significance (MGUS) and the level of c-MYC gene expression at the moment of disease diagnosis is studied. The expression of c-MYC in bone marrow cells was evaluated by multiplex RT-PCR. The mean levels of c-MYC gene expression in CD138+ cells of patients with MM/MGOO are higher than in donors (p = 0.011). Relationship between the depth of antitumor response and level of C-myc expression in CD138+ cells is detected.


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