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Role of granzyme B in T regulatory cells in patients after allogeneic stem cell transplantation


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The role of regulatory T-cells (T-reg) in the development of autoimmune complications after allogeneic bone marrow transplantation (allo-BMT) is to control the augmented response of donor effector cells. The main mechanisms of immune regulation are the secretion of cytokines, induction of metabolic disturbances in target cells, modification of dendritic cells, direct cytolysis of T effector cells. One of the regulatory mechanisms that use T-reg is a direct cytolysis, the major mediator is granzyme B. Granzyme B plays a key role in maintaining the immune homeostasis. Preliminary data from a qualitative and quantitative assessment of granzyme B-positive T-reg in 30 patients after allo-BMT endorse this role.

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