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Associations of polymorphism in several innate immunity genes with the risk of the development of chronic lymphoproliferative diseases


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Abstract

The complex interaction between environmental factors and human genes makes a significant contribution to the development of chronic lymphoproliferative diseases (CLPD) in individuals with mutations in various genes, including the innate immune response genes. We examined 51 patients with chronic lymphocytic leukemia (CLL) and 70 multiple myeloma (Mm) patients. The control group consisted of 47 healthy persons without hematological malignancies. The patients from control group were matched for gender and age characteristics of CLPD patients. In observed persons there was determined the prevalence of genetic polymorphisms (single-nucleotide polymorphism -SNP) in the innate immune response genes including 20 genetic polymorphisms (single-nucleotide polymorphism - SNP) in 14 genes of the innate immune response. In patients with CLL haplotype AA for the TLR3 gene in -421 position was revealed to occur significantly more often than in the control group (OR: 18.56; p = 0.005). In MM patients there was noted the relation between the risk of the development of the disease and gene polymorphism for IL-10-1082, TLR2-753 and TLR3-421. There were found genetic markers for rapidly progressing forms of CLL and MM (CG + GG haplotype of the gene IL-6 and haplotypes GG + GA gene IL-17A, respectively). It is possible to assume a probable link of gene polymorphisms for IL-6, IL-10, IL-17A, TLR2 and TLR3 with the development of the CLPD and recommend these markers as early additional diagnostic and prognostic criteria.


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