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ESTIMATION OF THE STATE OF METABOLIC ACTIVITY OF NEUTROPHILS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA


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Abstract

The functional activity of phagocytes of peripheral blood was analyzed. 63 children with acute lymphoblastic leukemia (ALL) were included in the study. The age of the patients (36 male and 17 female) was from 1 to 14 years. All patients received chemotherapy. The control group consisted from 79 healthy children (35 male and 44 female, aged from 10 to 14 years). The effect of myelosuppression of the chemotherapy in ALL children was revealed, which was manifested as the decline of the average cytochemical coefficient under the detection of the content of cationic complex protein and the decrease of phagocytic and metabolic activity of neutrophils in the nitro blue tetrazolium test.


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