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MOBILIZATION OF HEMATOPOIETIC STEM CELLS WITH CYCLOPHOSPHAMIDE OR CYTARABINE IN COMBINATION WITH GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS WITH MULTIPLE MYELOMA, WHO ARE CANDIDATES FOR AUTOLOGOUS STEM CELL TRANSPLANTATION


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Abstract

In our research the comparison of different regimes of mobilization of HSC were carried out. First regime: conduct stimulation of granulopoiesis using granulocyte colony-stimulating factor (GCSF). Other regimes: of mobilization with chemotherapy (cyclophosphamide or cytarabine). The efficiency and the toxicity were assessed. The grafts with satisfactory cellularity were obtained in 91% patients. The number of CD34+ cell/ml were obtained in the first apheresis and from whole mobilization in patients with complete remission (CR) were more than the number of in patients with < CR. CD34+ cell number in the blood correlate well with total number of CD34+ yielded from apheresis in same day. The number of CD34+ cells/microliter yielded from mobilization was more in group with сhemomobilization than in group with GCSF only. In comparison two groups of сhemomobilization: the number of CD34+ in peripheral blood in day apheresis was more in group with AraC-GCSF; р = 0.173. There was revealed lesser toxicity in group with AraC-GCSF.


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