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The actual condition of problem of evaluation of potential carcinogenic danger of lead and its compounds


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The wide application of lead in industry and global scope of anthropogenic pollution of environment with lead result in industrial and ecologically conditioned lead exposition of significant percentage of population of the Russian Federation. Notwithstanding that carcinogenicity of lead for animals is proved long ago and data concerning its genotoxic effect is presented and particular molecular mechanisms of its biological effect are decoded the issue of carcinogenicity of lead for human being is still open. The most significant issues preventing detecting cause-and-effect relations between lead exposition and risk of development of human malignant neoplasms are incorrect choice of studied industrial populations, which industrial exposition characterized by expressed confounding-effect; binary data analysis preventing identification of dependency “dose-effect”, limiting of studying industrial populations by male professional contingents.

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