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Antivirus preparation kagocel® exerts modulating multidirectional influence on blood serum cytokines profile forming by S. typhimurium antigen complex injection in CBA mice


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Abstract

Injection of interferon inducer Kagocel® to mice CBA (30 mkg per mouse) in 1 hour slightly increased (1,3-1,6 times) their blood serum cytokines concentrations IL 2,4, 10,12, IFNy and TNFa but in 3, 7 and 23 hours practically did not change them. Injection of S. typhimurium antigen complex to mice CBA increased in 2 and 4 hours their blood serum cytokines concentrations - IL2 (respectively 1,8 and 3,3 times), IL10 (4,7 and 2,9 times), IL12 (2,4 and 3,7 times), TNFa (1,3 and 1,6 times) and in 4 hours - IL4 (1,3 times), GM-CSF (2 times), IFNy (5,9 times). In 20 hours after S. typhimurium antigen complex injection blood serum cytokines concentrations corresponded to control level (IL-2, 4, 5, 10) or was lower than it 1,4-1,9 times (IFNy, ИЛ-12, TNFa). Injection of Kagocel® to mice 3 hours before injection of S. typhimurium antigen complex modulated blood serum cytokines profile forming by the latter in following way: for IL-10, 4, GM-CSF and TNFa (Group 1) decreased high (2 and 4 hours after S. typhimurium antigen complex injection) cytokines levels and increased law TNFa concentration (in 20 hours after S. typhimurium antigen complex injection), keeping them all on the control level or above it for IL-10; for IL-2, IFNy and IL-12 (Group 2) practically did not influenced on high cytokines concentrations (in 2 and 4 hours after S. typhimurium antigen complex injection) and increased their law concentrations (in 20 hours after S. typhimurium antigen complex injection) to level higher than normal in 1,4-1,8 times. On the whole it have been shown that Kagocel® exerts modulating multidirectional influence on blood serum cytokines profile forming by S. typhimurium antigen complex injection in CBA mice.


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