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IgE-mediated hypersensitivity as a response to barrier tissue disfunction


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The paper has given an insight of allergy as evolutionary selected reactivity for highly organized animals. This reactivity is directed to organization of allergen-specific inflammation and serves as biologically expedient, high-specific and high-sensitive reaction in response to allergen entering into the organism because of barrier tissue dysfunction. Such insight has provided the basis for a new preventive and therapeutic approach focused more on restituting of barrier allergen function than suppressing downstream allergic inflammation.

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