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The influence of modified bioflavonoid on effector lymphocytes in reaction of contact sensitivity in mice


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Abstract

Reaction of contact sensitivity in mice (CS) to 2,4-dinitrofluorobenzene (DNFB) is a model of the immune response in vivo, reproducing the disease contact dermatitis in humans. It is believed that with the development of the immune response is mediated predominantly by T lymphocytes, because these cells can adoptive transfer reaction from an experimental animal sensitized with non-sensitized. CS manifest in the form of inflammation (usually the skin) in place in getting repeat antigen. In our laboratory model of CS reproduced in CBA mice by dermal sensitization of DNFB. The aim of the study was to identify the mechanisms of immunomodulatory action of quercetin dihydrate and modified bioflavonoid using the method of adoptive transfer of contact sensitivity with splenocytes and T-lymphocytes. It was shown that the modified bioflavonoid more stronger suppress adoptive transfer of CS in comparison with quercetin dehydrate, without inducing apoptosis of effector cells.


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