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Autoimmune homeostasis evaluation in humans vaccinated against bacterial and viral respiratory infections


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Abstract

In current study we investigated the possibility of pathologic shifts in autoimmune homeostasis in humans, vaccinated against pneumococcal infection and seasonal influenza in 2014-2015 influenza season. Materials and Methods. The effects of antipneumococcal and antiinfluenza vaccinations were evaluated separately. IgM and IgG antibodies to double-strand DNA and cardiolipin, counts of rheumatoid factor, IgG antibodies to thyroglobulin were assayed at different time points in serum of all vaccinees. In persons, vaccinated against pneumococcal infection, we also evaluated counts of antibodies to cyclic citrullinated protein. In persons, vaccinated against influenza, counts of Th17 cells and T-regulatory cells were studied additionally. Results. Vaccination against pneumococcus induced temporary rise in anti-DNA antibodies, and prolonged rise of anticardiolipin antibodies, however, did not induce any symptomatic autoimmune disorder. Vaccination against seasonal influenza did not induce any changes in autoimmune homeostasis. Conclusion. All investigated vaccines did not induce any clinically apparent autoimmune diseases, however, antipneumococcal vaccination was able to increase intensity of humoral autoimmune reaction in its recipients.


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