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NOVEL TREATMENT STRATEGIES FOR PATIENTS WITH CANCER: IMMUNOTHERAPEUTIC APPROACH


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Abstract

In XXI century, new promising strategies for treating patients with cancer have been developed. The clinical use of targeted agents and immunotherapy has demonstrated high levels of efficacy against the number of malignancies. Further development of adoptive cell therapy has significantly increased immunological approaches to treatment. Administration of the immune checkpoint inhibitor class drugs has allowed to increase the overall survival rates more than twofold in comparison with chemotherapy. Despite the progress made, there are several unsolved problems. For example, no reliable predictors of efficacy of immunotherapy have yet been identified. We still don’t know how to determine reliably which patient can derive clinical benefit from immune targeted agents. Relatively low levels of response force us to pay attention to the combination of existing therapy lines. This article reviews the current immunotherapeutic approaches and combinative methods for treating oncologic patients, also giving some information about the potential predictive factors for immunotherapy appointment.


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