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PLASMA CYTOKINE LEVELS IN PRETERM NEWBORNS IN THE EARLY NEONATAL PERIOD


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Abstract

In this study we have investigated the plasma levels of chemokines (MCP, IL-8), proinflammatory (IFNγ, TNFα, IL-6, IL-1b, IL-12) and anti-inflammatory (IL-4, IL-10, IL-13) cytokines. Full-term, preterm newborns with respiratory disorders noninfectious origin and preterm newborns with congenital pneumonia were included in this study. Plasma of umbilical cord blood and peripheral blood at the 3rd day of life of newborns were examined by multiplex analysis. We have demonstrated that the plasma levels of studied cytokines were independent of gestational age. The levels of cord blood chemokines, pro- and anti-inflammatory cytokines was higher in the group of preterm newborns with congenital pneumonia compared with full-term and preterm newborns without signs of infection. In peripheral blood of newborns with pneumonia plasma levels of IFNγ, TNFα, IL-1b, IL-6, IL-12, IL-13, IL-4 were lower than in cord blood and the levels of IFNγ, IL-1b, IL-12, IL-4 were lower than in peripheral blood of preterm newborns with respiratory disorders of noninfected origin. In the control group the levels of MCP, IL-8, IL-6, IL-13, IL-12, IL-4 were higher in peripheral blood compared with cord blood.


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