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CLINICAL AND GENETIC ASPECTS OF NITRIC OXIDE METABOLISM IN CHILDREN WITH FOOD ALLERGY


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Abstract

To assess the fecal level of NO in food allergy (FA) children and the determination of the value of polymorphism G894T and T786S in eNOS gene in the development of FA children held clinical-laboratory examination of 39 children with the cow’s milk allergy. The comparison group consisted of 30 healthy children. During the study, all patients were divided into 2 subgroups: patients with IgE-dependent FA (n = 18) with elevated IgE levels (Me = 88.25; 95% CI: 52.18-184.98); patients with IgE- independent PA (n = 21) in which the level of total and specific IgE was comparable to the control group (Me = 15.0; 95% CI: 7.91-23.0). Our data strongly suggest the active participation NO in the development of FA children. The study showed that fecal levels of NO metabolites in children with IgE-dependent FA was significantly higher than the control group (336.61 ± 0.89 mmol/l and 270.42 ± 0.89 mmol/l, p = 0.0164), in IgE independent FA children NO metabolites were significantly lower (226.32 ± 0.89 mmol/l, p = 0.0074). No significant association of IgE-dependent and IgE independent FA with the presence of the T allele genotype of G894T in the eNOS gene was identified. Our study revealed an association of polymorphic loci eNOS CC 786 and TC 786 in the eNOS gene with an increased risk of food allergies in children (OR - 7,846 [95% CI; 1.897-32.450], p = 0.598). This carrier variant homozygous (CC) 786 eNOS increases the risk of IgE independent FA in 8.8 times and does not affect the risk of IgE-dependent FA children.


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