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DEVELOPMENT OF FOLLICULAR HELPER T CELLS


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Abstract

Follicular T helper cells (Tfh) represent the subpopulation of CD4+ T cells which specialize in providing help to B cells. Tfh are required for formation of germinal centers into the follicles of secondary lymphoid organs and stimulation of events that occur in these zones: the switching of immunoglobulin isotypes, affinity maturation, development of memory B cells and long-lived plasmocytes. Differentiation of Tfh is a multi-stage process, the final stages of which occur during cognate interactions with B-lymphocytes, in which B cells are both targets of helper action and stimulators of Tfh maturation. The review includes data on the maturation of Tfh, as well as on membrane molecules, cytokines, and nuclear factors involved in this process.


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