IMMUNOREGULATORY MECHANISMS OF PROGRESSION OF SEASONAL ALLERGIC RHINITIS

Despite numerous studies referring to seasonal allergic rhinitis (SAR), many problems, especially those related to the prognosis of clinical progression, are relevant. To generate ideas about the features of the functioning of the immune system in conditions of progression of the severity of SAR progress, the parameters of the innate and adaptive immune response in patients with mild to moderate severity of the active phase of SAR were studied. 62 people aged 18-50 y.o. who were divided into 2 groups (34 people with mild degree and 28 patients with moderate severity of SAR) were examined in accordance with Federal Clinical Recommendations, taking into account the assessment of severity of clinical symptoms (TNSS) and quality of life (RQLQ). The results of the analysis of the obtained data indicate that the changes in the immune status in patients with SAR of light and moderate severity during the clinical manifestation of allergy are unidirectional and are regulated by the intensification of the maturation processes, the functional features of the T- and B- effectors, the products of oppositely reacting mediators of the pro- and anti-inflammatory directivity in inhibiting readiness T-cells to apoptosis, mechanisms of immunosuppression, adaptive potential of neutrophils, lytic activity of natural killers. Progression of SAR from mild to moderate severity is associated with increased maturation of B cells, weakening of T-regulatory immunosuppression and aggravation of cytokine imbalance.

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