INTERLEUKINS-23, -12P40 AS MARKERS OF NEURAL TISSUE DAMAGE IN NEUROSYPHILIS
The purpose: to study the features of cytokines in patients with various forms of neurosyphilis. Material and methods. The complex laboratory examination of patients with neurosyphilis and syphilis without specific lesion of the nervous system was observed in the venereological department of the OSH “Clinical Dermatological and Venereological Dispensary” in Omsk in order to determine the concentration of interleukins - 23, 12p40 in CSF and assess their relationship with the course of syphilitic infection. Results: the presence of regularities and features in the deviation of the immune status in the examined disease was established. Conclusion. Analysis of immunological changes in patients’ cerebrospinal fluid showed that in patients with neurosyphilis, regardless of the presence or absence of clinical symptoms, the levels of IL-23 and IL-12p40 in CSF significantly exceed those in patients without specific lesion of the nervous system.
About the authorsNovikov Yuriy A.
Novikov A.I., Novikov Yu.A., Kidalov M.B., Romanov A.A., Radul E.V., Chermoshentsev A.A., Filippov S.O., Novgorodova T.I. Features of a course of neurosyphilis at the present stage. Omskiy nauchnyy vestnik. 2010; 1(94): 103-6. (in Russian)
Burdak V.N., Fedotov V.P., Manylova L.A., Pogorelov V.V. Clinical and laboratory parallels of changes in cerebrospinal fluid and the state of immune status in patients with early stages of syphilis. Vestnik dermatologii i venerologii. 1989; 10: 10-3. (in Russian)
Borisenko K.K., Basinskaya N.M., Mikheev N.A. Clinical and immunological characteristics of patients with syphilis. Vestnik dermatologii i venerologii. 1985; 7: 24-28. (in Russian)
Dyuzen I.V., Ivanis V.A., Mikhailov A.S., Menchinskaya E.S., Manzhulo N.V., Ogurtsova O.S. Investigation of the content of neuronal markers in certain infectious diseases. Tikhookeanskiy meditsinskiy zhurnal. 2015; 2: 27-30. (in Russian)
Esimova I.E., Urazova O.I., Novitsky V.V., Khasanova R.R., Filinyuk O.V. Secretion of interleukins IL-12, IL-27 by mononuclear leukocytes and expression of their receptors on T-lymphocytes under direct induction of cells in vitro in pulmonary tuberculosis. Meditsinskaya immunologiya. 2014; 3: 60-2. (in Russian)
Markelova E.V., Turmova E.P., Silaev A.A., Andreev D.B., Volkov V.V. The role of cytokines in the development of pneumonia after coronary artery bypass grafting in patients with coronary heart disease. Tikhookeanskiy meditsinskiy zhurnal. 2006; 2: 12-5. (in Russian)
Kawanokuchi J. et al. Production and function of IL-17 in microglia. J. Neuroimmunol. 2008; 194: 54-61.
Statement of selection and diagnostic tests on syphilis: method. instructions: the order from 3/26/2001 No. 87 / Medicin health care and social development of the Russian Federation//ConsultantPlus: - http://www.consultant.ru (in Russian)
Young H. Syphilis serology. Dermatol. Clin. 1998;16(4): 691-8.
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