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INTERLEUKINS-23, -12P40 AS MARKERS OF NEURAL TISSUE DAMAGE IN NEUROSYPHILIS


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Abstract

The purpose: to study the features of cytokines in patients with various forms of neurosyphilis. Material and methods. The complex laboratory examination of patients with neurosyphilis and syphilis without specific lesion of the nervous system was observed in the venereological department of the OSH “Clinical Dermatological and Venereological Dispensary” in Omsk in order to determine the concentration of interleukins - 23, 12p40 in CSF and assess their relationship with the course of syphilitic infection. Results: the presence of regularities and features in the deviation of the immune status in the examined disease was established. Conclusion. Analysis of immunological changes in patients’ cerebrospinal fluid showed that in patients with neurosyphilis, regardless of the presence or absence of clinical symptoms, the levels of IL-23 and IL-12p40 in CSF significantly exceed those in patients without specific lesion of the nervous system.


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