Динамика индикаторов эндотелиальной дисфункции при ожирении у детей

Введение. Конституционально-экзогенное ожирение (КЭО) относится к ряду значимых медико-социальных проблем современного мира, принимает масштабы эпидемии и лидирует среди алиментарно-зависимой патологии у детей. Цель работы - изучение изменений индикаторов эндотелиальной дисфункции при различной выраженности ожирения у детей. Материалы и методы. Комплексно обследованы 126 детей в возрасте 6-17 лет, из них 110 пациентов с различной выраженностью КЭО. В сыворотке крови определяли содержание медиаторов эндотелиальной дисфункции: оксида азота, эндотелина-1, лептина, гомоцистеина, молекул межклеточной адгезии и адгезии сосудистых клеток-1, антигена ингибитора активатора плазминогена тканевого типа, фактора Виллебранда и его антигена. Результаты. Установлены закономерности изменений концентраций указанных соединений в крови в зависимости от возраста больных и степени ожирения, отражающие нарушения функционального состояния эндотелиальной системы. Заключение. Индикаторы эндотелиальной дисфункции могут служить критериями её выраженности, их выявление позволит оптимизировать раннюю диагностику и определить объём своевременной терапии.

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