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The role of hepcidin in the development of anemia in children with inflammatory bowel disease


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Abstract

Anemia is a common complication and extraintestinal manifestation of the inflammatory bowel disease (IBD). There are presented data of the quantitative analysis of hepcidin in the serum of IBD patients for the differential diagnosis of various variants of anemia. The study involved 186 IBD patients aged from 1 year to 18 years (mean age 13 ± 4,7 years). Out of them there were 57patients with ulcerative colitis and 81 - with Crohn's disease, with the disease duration from 2 months up to 12 years. 48 apparently healthy children of the same age were considered as the reference group. In IBD patients, regardless of the presence of anemia hepcidin blood level was established to be elevated if compared with healthy donors. The analysis showed that only patients with isolated anemia of chronic disease (ACD) had a significant increase in the blood concentration of hepcidin if compared to children without anemia, isolated iron deficiency anemia and mixed anemia. The area under the curve (AUC) for hepcidin when comparing patients with mixed anemia and cases with isolated ACD was 0.81, and among all the indices of iron metabolism it was the largest that has allowed to use this index for the differential diagnosis of various pathogenic variants of anemia in IBD. The authors believe that the measurement of hepcidin serum level can be used as an additional marker of anemia in children with IBD.


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