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Intestinal microbiota and atopic dermatitis in children


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Abstract

There are presented data on the role of the intestinal microbiota in the formation of atopic dermatitis (AD). The intestinal microbiota of human was established to be evolutionarily developed array of micro-organisms, existing as the microecological balanced system in which the symbiotic microflora is in dynamic equilibrium and forms microbial associations occupying in it a certain ecological niche. The intestinal flora was shown to play an important role in the development of baby’s immune system and has a protective effect against atopy. There was determined the value of the intestinal microbiota in its interaction with the immune system, as a factor of sensitization of children. Therefore, the «hygienic» hypothesis of AD is now complemented by the concept of «microbial deprivation», which is considered the insufficient microbial colonization from the birth as an important risk factor for the development of allergic diseases. The microbial colonization in infants has been shown to be subjected to the impact of exogenous factors, including the mode of delivery, type of feeding, the use of antibiotics and peculiarities of the introduction of supplementary foods. There is delivered an assertion that early manipulations with intestinal microbial communities can become the basis of a new strategy for the prevention of allergic sensitization. There is considered the preventative and therapeutic effect of new drugs with a probiotic action, which use differences in the microbiota for the treatment and prevention of atopic dermatitis.


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