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FEATURES OF THE IMMUNE STATUS IN ATOPIC BRONCHIAL ASTHMA CHILDREN IN DEPENDENCE ON THE LEVEL OF THE THERAPY CONTROL


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Abstract

Introduction. Inflammation plays an important role in the pathogenesis of bronchial asthma (BA). We have made the hypothesis immunological indices to differ in children with various levels of the therapy control of atopic BA. Materials and methods. We have examined 37 children aged 8-17 years. The main group was divided into two subgroups: 1A (12 patients with controlled BA), 1B (12 patients with partially controlled and uncontrolled BA). Comparison group 2 consisted of 13 patients with non-immune diseases. Results. Levels of eosinophils, T-cytotoxic lymphocytes (CD8+ cells), B-cells (CD20+ cells), IgM, IgE and phagocytic activity of neutrophils in BA children differed significantly from the data in cases from comparison groups Conclusion. In patients with the controlled course of BA disorders were manifested as a moderate immunodeficiency. Children with uncontrolled asthma showed increased levels of indices related to the allergic inflammation process. Children with controlled BA have a moderate immunodeficiency with a 25% decrease of non-specific factors of the defense and humoral immunity: the number of B-lymphocytes, level of IgM, along with a slight change in indices related to allergic process, low level of eosinophilia and IgE production. Children with uncontrolled BA also have the dysbalance of the immune system due to the state of hyperactivity with the 3-fold increase in eosinophils, 1,3-fold increase in CD8+ lymphocytes, 7-fold increase in the IgE level. The more evident imbalance of the immune system in children with uncontrolled BA is confirmed by a 2-fold increase of correlations between the indices characterizing the state of the immune system, 2.6-fold increase of strong (0,70


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