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ALLERGIC BRONCHIAL ASTHMA IN CHILDREN: FEATURES OF THE DEVELOPMENT AND MODERN THERAPY


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Abstract

In the review, based on the data of the modern literature and authors’ own research, features of the development of allergic bronchial asthma (BA) in children are presented. There is also considered the important role of atopy, IgE-mediated mechanism, activation of Th2-lymphocytes, mast cells, basophils, eosinophils, increased production of mediators, chemokines and cytokines (IL4, IL5, IL8, IL13, IL17, IL22, IL25, IL33, GM-CSF, TNFα) in its pathogenesis and Th2 endotypes and phenotypes of allergic asthma. Modern therapeutic approaches to the treatment of allergic asthma based on the use of inhaled glucocorticosteroids, leukotriene receptor antagonists, short and long-acting β2-agonists, long-acting theophylline, omalizumab, and allergen-specific immunotherapy have been determined.


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