ADIPOKINES AND HORMONES IN CHILDREN OF PRIMARY SCHOOL AGE WITH NORMAL AND EXCESS BODY WEIGHT

Prevention and early diagnosis of obesity in children is an urgent task. For this, biologically active peptides and hormones regulating the metabolism of adipose tissue can be used. The authors evaluated the nutritional status of 652 children aged 7-10 years living in Moscow and attending general education schools. Among these children, the case-control method was used to select 40 patients with overweight / obesity and 38 schoolchildren with normal weight and height (comparison group). Blood was taken from all children to quantify hormones and adipokines. Serum concentrations of hormones (ghrelin, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon), C-peptide and adipokines (adiponectin, adipsin, leptin, tissue plasminogen-activator inhibitor-1, resin, visfatin) in the blood sample were evaluated with the use of method of flow cytometry. There was found a significant increase in adipokine and hormone blood concentrations, depending on the degree of the disorder of the nutritional status of children. In makes them to consider as early biomarkers of obesity with diagnostic and prognostic significance.

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