OPTIMIZATION OF TREATMENT TACTICS FOR ACUTE VIRAL GASTROENTERITIS IN IN-PATIENT CHILDREN
Acute intestinal infections (ACI) being a common form of pathology in children, 50-80% of cases are due to viral agents with a predominance of rotavirus. Patients Over a two-year period, 2556 children aged from 3 months and up to 18 years old were treated in the Department of acute intestinal infections. Two groups of children with viral intestinal infections without extraintestinal bacterial foci were selected. The main group consisted of 259 children who received diet therapy, oral rehydration (ORR) and, according to indications, infusion therapy (IT). 248 children included in the comparison group (CG) received ORP, nitrofurans, antibacterial drugs, enterosorbents, enzymes, probiotics, and, according to indications, IT. Results. In no case did the children of OG receive antibacterial drugs; Compliance with parents allowed IT to be minimized to 17.4% of cases (45 children). In CG, in 74.2% of cases (184 children), patients, in addition to nitrofurans, received III generation cephalosporins, in 81.9% of cases - IT, all children received probiotics, enzymes as symptomatic therapy. Following the recommendations of WHO and ESPGHAN allows avoiding polypharmacy and reduce the economic costs of treating in-patient children with viral gastroenteritis by 3.3 times.
About the authorsMaltseva Yulia V.
Rose M.A. Mucosal Immunity and acute viral gastroenteritis. Hum. Vaccin. Immunother. 2014; 10(7): 2112-4. Doi: 10.4161/hv.29605.
Usenko D.V., Ploskireva A.A., Gorelov A.V. Acute intestinal infections in children in pediatric practice: possibilities of diagnosis and therapy Voprosy sovremennoy pediatrii. 2014; 13 (3): 12-20. (in Russian)
Bulanova I.A., Titova L.V., Samodova O.V., Feklisova L.V. Rota- and norovirus infections in young children in the Arkhangelsk region. EpiNort. 2009; 10(1): 18-24. (in Russian)
Glass R. I., Parashar U. D., Estes M. K. Norovirus gastroenteritis. N. Engl. J. Med. 2009; 361: 1776-85.
Lyman W.H., Walsh J.F., Kotch J.B., Weber D.J., Gunn E., Vinje J. Prospective study of etiologic agents of acute gastroenteritis outbreaks in child care centers. J. Pediatr. 2009; 154: 253-7.
Gorelov A.V., Usenko D.V. Rotavirus infection in children. Voprosy sovremennoy pediatrii. 2008; 7 (6): 78-84. (in Russian)
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases Evidence-Based Guidelines for the Management of Acute Gastroenteritis in Children in Europe: Update 2014. JPGN. 2014; 59: 132-52. Doi: 10.1097/MPG.0000000000000375.
Grekova A.I., Zharkova L.P. Selection of antibiotic therapy in children (Results of multicenter analytical study). Pediatric pharmacology. 2007; 4(4): 16-9. (in Russian)
Tatochenko V.K. Diagnostic and therapy in children’s acute gastroenteritis. Voprosy sovremennoy pediatrii. 2007; 6(3):18-23. (in Russian)
Luk’yanova A.M., Bekhtereva M.K., Ptichnikova N.N. Clinical and epidemiological characteristics of viral diarrhea in children. Zhurnal infektologii. 2014; 6(1): 60-6. (in Russian)
Farthing M, Salam M, Lindberg G, Dite P., Khalif I., Salazar-Lindo E. et al. Acute diarrhea in children and adults: a global perspective. World Gastroenterology Organisation. 2012.
Walker C.L., Rudan I., Liu L., Nair H., Theodoratou E., Bhutta Z.A. et al. Global burden of childhood pneumonia and diarrhea. Lancet. 2013; 381: 1405-16. Doi: 10.1016/S0140-6736(13)60222-6.
Khayat N., Chirouze C., Tran T.A., et al. Clinical analysis of antibiotic treatment of acute gastroenteritis in infants and young children. Arch Pediatr. 2002; 9 (12): 1230-5.
Oldak E., Rozkiewicz D., Sulik A., Pogorzelska E., Al-Hwish M.A. Antibiotic use for acute gastroenteritis in ambulatory care of children before and after implementation the healthcare system reform in Poland. Pol Merkur Lekarski. 2006; 20(116): 155-8.
Kulichenko T.V., Bakradze M.D., Patrusheva Yu. S. Acute infectious diarrhea in children. Pediatricheskaya farmakologiya. 2009; 6(3): 97-103. (in Russian)
Ruuska T, Vesikari T. Rotavirus disease in Finnish children: use of numerical scores for clinical severity of diarrhoeal episodes. Scand J Infect Dis. 1990; 22: 259-67.
Yeskov K.A., Khadartsev A.A., Filatova O.E., Khadartseva K.A. Living systems from the standpoint of the theory of chaos-self-organization. Vestnik novykh meditsinskikh tekhnologiy. 2015; 22(3): 25-30. (in Russian)
Yagudina R.I., Serpik V.G. The methodology of cost-benefit analysis. Farmakoekonomika. Teoriya i praktika. 2016; 2(4): 5-9. (in Russian)
Uchaikin V.F. Guideline for infective diseases in children [Rukovodstvo po infektsionnym boleznyam u detey]. (Ed A.V. Gordeets, F.S. Kharlamova). Moscow; GEOTAR MED; 2004. (in Russian)
Ploskireva A.A., Gorelov A.V. Pathogenetic therapy of acute intestinal infections in children: an integrated approach. RMZH «Meditsinskoe obozrenie». 2018; 8(2): 79-82. (in Russian)
Lobzin Y.V, Anokhin V.A., Khaliullina S.V. Acute intestinal infections in children. A new look at the old problem. Rossiyskiy mediko-biologicheskiy vestnik imeni akademika I.P. Pavlova. 2014; 3: 40-7. (in Russian)
Fisenko A.P., Kaliuzhnaia T.A., Makarova S.G., Shakhtakhtinskaya F.Ch., Kurdup M.K., Tkachenko N.E. et al. Immunization against rotavirus infection as an approach to prophylaxis of acute gastroenteritis in infants. Rossiyskiy pediatricheskiy zhurnal. 2019; 22(3): 132-6. DOI: http://dx.doi.org/10.18821/1560-9561-2019-22-3-132-136. (in Russian)
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