ULTRASONIC CHARACTERISTICS OF THE STRUCTURE OF THE LIVER CAPSULE IN HEALTHY CHILDREN OF DIFFERENT AGES

Ultrasound examination (ultrasound) takes the first place first among visual methods for analyzing the state of the liver parenchyma. Despite the improvement of ultrasound technology, it does not provide the necessary diagnostic accuracy in determining the stages of liver fibrosis. In this regard, it is necessary to search for additional diagnostic criteria to judge the state of the liver tissue and its superficial structures, primarily liver capsules.Materials and methods: the state of the liver capsule was assessed in 73 children of four age groups (2-18 years) without pathological changes in the hepatobiliary system, which were performed by ultrasound of the abdominal organs during preventive examinations. The structure of the capsule of the liver and visceral peritoneum was evaluated. Results. Direct dependence of the thickness of the liver capsule on the age of children was established (rs = 0.577, p = 0.0000). The capsule and visceral peritoneum represented a single and even echogenic structure (95.9%). Stratification of the leaves was detected in 8 children. A change in the shape of the edge of the right lobe of the liver was observed in 4 children. An increase in the severity of subcapsular blood flow in the liver was not detected in any healthy child.

Haubrich WS. Glisson of Glisson’s capsule of the liver. Gastroenterology. 2001; 120(6): 1362.

Walker RM. Francis Glisson and his capsule. Ann R Coll Surg Engl. 1966; 38(2): 71-91. DOI: 10.1016/s0016-5085(01)87930-0.

Xiang Liu, Jia Lin Song, Shuo Hong Wang, Jing Wen Zhao, Yan Qiu Chen. Learning to Diagnose Cirrhosis with Liver Capsule Guided Ultrasound Image Classification. Sensors. 2017; 17: 149; doi:10.3390/s17010149.

Xu S, Kang CH, Gou X, Peng Q, Yan J, Zhuo S. et al. Quantification of liver fibrosis via second harmonic imaging of the Glisson’s capsule from liversurface. J Biophotonics. 2016; 9(4): 351-63. doi: 10.1002/jbio.201500001.

Roan E. The effect of Glisson’s capsule on the superficial elasticity measurements of the liver. J Biomech Eng. 2010; 132(10): 104504. doi: 10.1115/1.4002369.

Borro P, Dellepiane SG, Pellicano R, Gemme L, Fagoonee S, Testino G. Quantification of ultrasound imaging in the staging of hepatic fibrosis. Panminerva Med. 2018; 60(2): 44-51. doi: 10.23736/S0031-0808.18.03416-X.

Dvoryakovskaya G.M., Ivleva S.A., Dvoryakovsky I.V., Potapov A.S., Chetkina T.S., Smirnov I.E. Ultrasonic methods of quantitative assessment of the structure of the liver parenchyma in healthy children. Rossiyskiy pediatricheskiy zhurnal. 2013; 1: 31-7. (in Russian)

Dvoryakovskiy I.V., Ivleva S.A., Dvoryakovskaya G.V., Surkov A.N., Potapov A.S., Smirnov I.E. Modern technologies of ultrasound diagnostics of cirrhosis in chronic liver diseases in children. Rossiyskiy pediatricheskiy zhurnal. 2016; 19(4): 202-8. doi 10.18821/1560-9561-2016-19-4-202-208. (in Russian)

Lee SM, Lee JM, Kang HJ, Yang HK, Yoon JH, Chang W. et al. Liver fibrosis staging with a new 2D-shear wave elastography using comb-push technique: Applicability, reproducibility, and diagnostic performance. PLoS One. 2017; 12(5): e0177264. doi: 10.1371/journal.pone.0177264.

Xie LT, Yan CH, Zhao QY, He MN, Jiang TA. Quantitative and noninvasive assessment of chronic liver diseases using two-dimensional shear wave elastography. World J Gastroenterol. 2018; 24(9): 957-70. doi: 10.3748/wjg.v24.i9.957.

Ivleva S.A., Dvoryakovskaya G.V., Dvoryakovskiy I.V., Potapov A.S., Volynets G.V., Smirnov I.E. The innovative ultrasonic method of assessment of the liver parenchyma in children with chronic hepatitis C. Rossiyskiy pediatricheskiy zhurnal. 2015; 18(3): 9-14. (in Russian)

Dvoryakovskaya G.M., Ivleva S.A., Dvoryakovskiy I.V., Surkov A.N., Potapov A.S., Gundobina O.S., Smirnov I.E. Comprehensive ultrasound diagnosis in the evaluation of liver parenchyma and stages of fibrosis in children with autoimmune hepatitis. Rossiyskiy pediatricheskiy zhurnal. 2016; 19 (1): 4-8. (in Russian)

Surkov A.N., Smirnov I.E., Kucherenko A.G., Potapov A.S., Tumanova E.L. The dynamics of markers of fibrosis in chronic liver diseases in children. Rossiyskiy pediatricheskiy zhurnal. 2009; 3: 23-7. (in Russian)

Surkov A.N., Smirnov I.Ye., Kucherenko A.G., Potapov A.S., Gerasimova N.P., Zinovyeva A.Ye. Relationships of serum fibrosis markers to hepatic structural and functional changes in children. Rossiyskiy pediatricheskiy zhurnal. 2010; 2: 28-31. (in Russian)

Friedrich-Rust M, Muller C, Winckler A, Kriener S, Herrmann E, Holtmeier J, et al. Assessment of liver fibrosis and steatosis in PBC with FibroScan, MRI, MR-spectroscopy, and serum markers. Journal of Clinical Gastroenterology. 2010; 44: 58-65. doi: 10.1097/MCG.0b013e3181a84b8d.

Pietrobattista A., Alterio A., Natali G., Fruhwirth R., Comparcola D., Sartorelli M., Nobili V. Needle Biopsy in Children With Liver Diseases. Liver Biopsy in Modern Medicine. 2011; 253-64. doi: 10.5772/19383.

Sharma S, Khalili K, Nguyen GC. Non-invasive diagnosis of advanced fibrosis and cirrhosis. World J Gastroenterol. 2014; 20(45): 16820-30.

Markin P.G. Method of complex morphometric assessment of liver capsule. Pat.No. 2153851 the Russian Federation, IPC A 61 B 10/00. declared. 30.03.1999 publ. 10.08.2000. (in Russian)

Buschmann RJ, Ryoo JW. Hepatic structural correlates of liver fibrosis: a morphometric analysis. Experimental and Molecular Pathology. 1989; 50(1): 114-24. doi: 10.1016/0014-4800(89)90061-0.

Martinez SM, Crespo G, Navasa M, Forns X. Noninvasive assessment of liver fibrosis. Hepatology 2011; 53: 325-35. doi: 10.1002/hep.24013.

B A, Rao S, Pandya HJ. Engineering approaches for characterizing soft tissue mechanical properties: A review. Clin Biomech (Bristol, Avon). 2019; 69: 127-40. doi: 10.1016/j.clinbiomech.2019.07.016.