Age-related features of gastritis activity in schoolchildren with gastroesophageal reflux disease
Aim. To study age-related features of the association of gastroesophageal reflux disease (GERD) with the activity of the inflammatory process in the gastric mucosa (GM) in schoolchildren. Materials and methods. At the first stage in the Republic of Tuva, we collected data on the presence of gastroenterological complaints in 1535 schoolchildren using a transverse method. At the second stage we performed esophagogastroduodenoscopy with biopsy of the mucous membrane of the antrum and the body of the stomach in two hundred forty six children including 76 cases aged from 7-11 years and 170 patients aged from 12 to 17 years. Morphological assessment of gastritis was carried out according to the Sydney classification after staining biopsy sections with hematoxylin-eosin; diagnostics of Helicobacter pylori - after staining by Giemsa method. The study was approved by the ethical committee and the consent of the surveyed patients was obtained. Results. An increase in the prevalence of GERD was found in the older age group of schoolchildren - 15.6% (7-11 years old - 4.7%; p = 0.0001). GERD schoolchildren showed an insignificant tendency with age to an increase in the activity of the inflammatory process in the mucous membrane of the antrum (p = 0.3408) and the body (p = 0.3346) of the stomach. Among infected GERD schoolchildren in both age groups, gastritis with a high degree (II-III degree) of activity was more often detected than in infected schoolchildren without clinical manifestations of GERD (7-11 years old - p = 0.2551; 12-17 years old - p = 0.0536, respectively) and more often than in those uninfected GERD cases (7-11 years old - p = 0.0082; 12-17 years old - p = 0.0002). The association of highly active forms of gastritis in the body of the stomach in infected schoolchildren with manifestations of GERD has not been established. Conclusion. The presence of GERD in schoolchildren, regardless of age, aggravates the course of the inflammatory process in the antrum. When infected with Helicobacter pylori, GERD and infection in schoolchildren act as factors that mutually aggravate the inflammatory process in the antrum.
About the authorsPolivanova Tamara V.
Kasparov Eduard V.
Vshivkov Vitaliy A.
El-Serag H.B., Sweet S., Winchester C.C., Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014; 63(6): 871–80. https://doi.org/10.1136/gutjnl-2012-304269
Katz P.O., Gerson L.B., Vela M.F. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am. J. Gastroenterol. 2013; 108(3): 308–28. https://doi.org/10.1038/ajg.2012.444
Eusebi L.H., Ratnakumaran R., Yuan Y., Solaymani-Dodaran R., Bazzoli F., Ford A.C. Global prevalence of and risk factors for gastroesophageal reflux symptoms: a meta-analysis. Gut. 2018; 67(3): 430–40. https://doi.org/10.1136/gutjnl-2016-313589
Hunt R., Armstrong D., Kateralis P., Afihene M., Bane A., Bhatia S., et al. World Gastroenterology Organisation global guidelines: GERD global perspective on gastroesophageal reflux disease. J. Clin. Gastroenterol. 2017; 51(6): 467–78. https://doi.org/10.1097/MCG.0000000000000854
Mousa H., Hassan M. Gastroesophageal reflux disease. Pediatr. Clin. North. Am. 2017; 64(3): 487–505. https://doi.org/10.1016/j.pcl.2017.01.003
Polivanova T.V., Vshivkov V.A. The relationship of family predisposition for gastric pathology with GERD and erosive-ulcerative lesions of the gastroduodenal zone in schoolchildren in Siberia. Yakutskiy meditsinskiy zhurnal. 2020; (2): 88–92. https://doi.org/10.25789/YMJ.2020.70.26 (in Russian)
Aksel’ E.M. Gastrointestinal cancer statistics. Sibirskiy onkologicheskiy zhurnal. 2017; 16(3): 5–11. https://doi.org/10.21294/1814-4861-2017-3-5-11 (in Russian)
Tsukanov V.V., Khomenko O.V., Rzhavicheva O.S., Butorin N.N., Shtygasheva O.V., Maady A.S., et al. The prevalence of Helicobacter pylori and GERD in Mongoloids and Caucasoids of Eastern Siberia. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. 2009; 19(3): 38–41. (in Russian)
Bichurina T.B., Vasyutin A.V. Prevalence and clinical manifestations of Barrett’s esophagus in the Republic of Tyva. Zabaykal’skiy meditsinskiy vestnik. 2013; (2): 131–5. (in Russian)
Graham D.Y. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer. World J. Gastroenterol. 2014; 20(18): 5191–204. https://doi.org/10.3748/wjg.v20.i18.5191
Tack J., Pandolfino J.E. Pathophysiology of gastroesophageal reflux disease. Gastroenterology. 2018; 154(2): 277–88. https://doi.org/10.1053/j.gastro.2017.09.047
Sherman P.M., Hassall E., Fagundes-Neto U., Gold B.D., Kato S., Koletzko S., et al. A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population. Am. J. Gastroenterol. 2009; 104(5): 1278-95. https://doi.org/10.1038/ajg.2009.129
Dixon M.F., Genta R.M., Yardley J.H., Correa P. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis. Helicobacter. 1997; 2(Suppl. 1): 17–24. https://doi.org/10.1111/j.1523-5378.1997.06b09.x
Sugano K., Tack J., Kuipers E.J., Graham D.Y., El-Omar E.M., Miura S., et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015; 64(9): 1353–67. https://doi.org/10.1136/gutjnl-2015-309252
Rebrova O.Yu. Description of statistical data analysis in the original articles. Typical mistakes. Meditsinskie tekhnologii. Otsenka i vybor. 2011; (4): 36–40. (in Russian)
Leung A.K., Hon K.L. Gastroesophageal reflux in children: an updated review. Drugs Context. 2019; 8: 212591. https://doi.org/10.7573/dic.212591
Broeva M.I., Surkov A.N., Chernikov V.V. Current issues of diagnosis and treatment of functional gastrointestinal disorders in children. Pediatricheskaya farmakologiya. 2017; 14(6): 527–34. https://doi.org/10.15690/pf.v14i6.1837 (in Russian)
Correa P. Helicobacter pylori and gastric carcinogenesis. Am. J. Surg. Pathol. 1995: 19(1): 37–43.
Noto J.M., Peek R.M. Jr. The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer. PLoS Pathog. 2017; 13(10): e1006573. https://doi.org/10.1371/journal.ppat.1006573
Tsukanov V.V., Barkalov S.V., Tonkikh Yu.L., Shtygasheva O.V., Barmakov A.E., Bronnikova E.P., et al. Prevalence of Helicobacter pylori CagA strains and peptic ulcer in the population of Eastern Siberia. Terapevticheskiy arkhiv. 2007; 79(2): 15–8. (in Russian)
Polivanova T.V., Vshivkov V.A. Prevalence of H. pylori CagA strain and characteristics of associated gastritis in schoolchildren with dyspepsia syndrome in Tyva Republic. Eksperimental’naya i klinicheskaya gastroenterologiya. 2014; (9): 52–5. (in Russian)
Для цитирования: Поливанова Т.В., Каспаров Э.В., Вшивков В.А. Возрастные особенности активности гастрита у школьников с гастроэзофагеальной рефлюксной болезнью. Российский педиатрический журнал. 2022; 25(2): 116–120. https://doi.org/10.46563/1560-9561-2022-25-2-116-120
For citation: Polivanova T.V., Kasparov E.V., Vshivkov V.A. Age-related features of gastritis activity in schoolchildren with gastroesophageal reflux disease. Rossiyskiy pediatricheskiy zhurnal (Russian Pediatric Journal). 2022; 25(2): 116–120. (In Russian). https://doi.org/10.46563/1560-9561-2022-25-2-116-120
- Refbacks are not listed
Контент доступен под лицензией Creative Commons Attribution 3.0 License.