| NARCOLOGY (2005)
Sivolap Yu.P., Savchenkov V.A. The monograph is dedicated to theoretical and practical aspects of a problem of
opioid abuse and dependence and consists of three parts. The first part incorporates the
latest knowledge on pharmacology of opioids and neurobiology of opioid dependence. Besides
the common intelligence the data on pharmacology, toxicology and abuse potential of
separate opioids — both street drugs and medicinal preparations — are considered. The
second part covers clinical questions of opioid abuse. Besides the phase conditions of
opioid dependence (drug intoxication, withdrawal, postwithdrawal state and remission) the
questions of psychopathology of opioid dependence such as infectious, visceral and
neurological consequences of opioid abuse are highlighted. The third part focuses on the
basic models of opioid dependence treatment with the analysis of advantages and
disadvantages of each of them. Methadone maintenance and other programmes of opioid
substitution are minutely considered.
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