Àíåñòåçèîëîãèÿ è ðåàíèìàòîëîãèÿ ¹6 2008

Áåëîáîðîäîâà Í. Â., Äìèòðèåâà È. Á., ×åðíåâñêàÿ Å. À.

Ñåïñèñ-èíäóöèðîâàííûé èììóíîïàðàëè÷: ïàòîãåíåç, äèàãíîñòèêà è âîçìîæíûå ïóòè êîððåêöèè

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1. Monneret G. How to identify systemic sepsis-induced immunoparalysis // Advances in sepsis. — 2005. — Vol. 4, N 2. — P. 42—49.
2. Hotchkiss R. S., Karl El. The pathophysiology and treatment of sepsis // N. Engl. J. Med. — 2003. — Vol. 348. — P. 138—150.
3. Harbarth S., Garbino J., Pugin J. et al. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis // Am. J. Med. — 2003. — Vol. 115. — P. 529—535.
4. Dellinger R. P., Carlet J. M., Masur H. et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock // Crit. Care Med. — 2004. — Vol. 32. — P. 858—873.
5. G. G. Gomez, Ñ. A. Kruse Mechanisms of malignant glioma immune resistance and sources of immunosuppression // Gene Ther. Mol. Biol. — 2006. Vol. 10a. — P. 133—146.
6. Thomas D. A., Massague J. TGF-b directly targets cytotoxic T cell functions during tumor evasion of immune surveillance // Cancer Cell. — 2005. — Vol. 8. — P. 369—380.
7. D. P. Nelson, E. Setser, D. G. Hall, S. M. Schwartz, T. Hewitt, R. Klevitsky, H. Osinska, D. Bellgrau, R. C. Duke, J. Robbins. Proinflammatory consequences of transgenic Fas ligand expression in the heart // J. Clin. Invest. — 2000. — Vol. 105 (9). — P. 1199—1208.
8. Garantziotis S., Brass D. M., Savov J., Hollingsworth J. W., McElvania-Tekippe E., Berman K., Walker J. L., Schwartz D. A. Leukocyte-derived Interleukin-10 Reduces Subepithelial Fibrosis Associated with Chronically Inhaled Endotoxin // J. Respir. Cell. Mol. Biol. — 2006. Jun 29; [Epub ahead of print].
9. Vreugdenhil H. A., Lachmann B., Haitsma J. J., Zijlstra J., Heijnen C. J., Jansen N. J., van Vught A. J. Exogenous surfactant restores lung function but not peripheral immunosuppression in ventilated surfactant-deficient rats // Exp. Lung. Res. — 2006. Jan—Feb; — Vol. 32 (l—2). — P. 1—14.
10. Di Vita G., Patti R., D’Agostino P., Caruso G., Arcara M., Buscemi S., Bonventre S., Ferlazzo V., Arcoleo F., Cillari E. Cytokines and growth factors in wound drainage fluid from patients undergoing incisional hernia repair // Wound. Repair. Regen. — 2006. — Vol. 14 (3). — P. 259—264.
11. Finnerty C. C., Herndon D. N., Przkora R., Pereira C. T., Oliveira H. M., Queiroz D. M., Rocha A. M., Jeschke M. G. Cytokine expression profile over time in severely burned pediatric patients // Shock. — 2006. — Vol. 26, N l. — P. 13—19.
12. Straub R. H., Pongratz G., Weidler C., Linde H. J., Kirschning C. J., Gluck T., Scholmerich J., Falk W. Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes // J. Infect. Dis. — 2005. — Vol. 192, N 4. — P. 560—572.
13. Àëåêñååâ Ñ. À., Ãàèí Þ. Ì., Áîãäàí Â. Ã., Ñîêîëîâ Þ. À. Ïðîáëåìà àáäîìèíàëüíîãî ñåïñèñà â õèðóðãèè. Ñîîáùåíèå 6: Èììóííûå íàðóøåíèÿ è èõ äèàãíîñòèêà // ÁÃÌÓ-Èíôîðìàöèÿ-ÁÌÆ. — 2002. — ¹ 2.
14. Cavaillon J. M., Adrie Ñ., Fitting Ñ., Adib-Conque M. Reprogramming of circulatory cells in sepsis and SIRS // J. Endotoxin. Res. — 2005. — Vol. 1, N 5. — P. 311—320.
15. Nuntaprasert A., Mori Y., Muneta Y., Yoshihara K., Tsukiyama-Kohara K., Kai C. The effect of recombinant swine interleukin-4 on swine immune cells and on pro-inflammatory cytokine productions in pigs // Comp. Immunol. Microbiol. Infect. Dis. — 2005. — Vol. 28, N 2. — P. 83—101.
16. Saeftel M., Krueger A., Arriens S., Heussler V., Racz P., Fleischer B., Brombacher F., Hoerauf A. Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice // Infect. Immun. — 2004. — Vol. 72, N 1. — 322—331.
17. Nakagawa Y., Murai T. Staphylococcal peptidoglycan suppresses production of interleukin-2 by T cells through a T cell-derived factor induced by direct contact between T cells and monocytes // J. Infect. Dis. —2003. — Vol. 188, N 9. — P. 1284—1294.
18. Volk H. D., Reinke P., Docke W. D. Clinical aspects: From systemic inflammation to "immunoparalysis" // Chem. Immunol. — 2000. — Vol. 74. — P. 162—167.
19. Dugernier T. L., Laterre P.-F., Wittebole X. et al. Compartmentalization of the inflammatory response during acute pancreatitis // Am. J. Respir. Crit. Care Med. — 2003. — Vol. 168. — P. 148—157.
20. Fitting C., Dhawan S., Cavaillon J. M. Compartmentalization of tolerance to endotoxin // J. Infect. Dis. — 2004. — Vol. 189. — P. 1295—1303.
21. Suzuki K., Nakaji S., Yamada M., Totsuka M., Sato K., Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics // Exerc. Immunol. Rev. — 2002. — Vol. 8. — P. 6—48.
22. Wu R. Q., Xu Y. X., Song X. H., Chen L. J., Meng X. J. Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture // World J. Gastroenterol. — 2002. — Vol. 8, N l. — P. 131—134.
23. Hynninen M., Pettila V., Takkunen Î. et al. Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and –10 levels in critically ill patients with sepsis // Shock. — 2003. — Vol. 20. — P. 1—4.
24. Monneret G., Finck M. E., Venet F. et al. The anti-inflammatory response dominates after septic shock // Immunol. Lett. — 2004. — Vol. 95. — P. 193—198.
25. Lekkou A., Karakantza M., Mouzaki A. et al. Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections // Clin. Diagn. Lab. Immunol. — 2004. — Vol. 11. — P. 161—167.
26. Friedman G., Yankowski S., Marchant A., Goldman M., Kahn R. J., Vincent J. L. Blood interleukin 10 levels parallel the severity of septic shock // J. Crit. Care 1.
27. Nakagome K., Dohi M., Okunishi K., Tanaka R., Miyazaki J. I., Yamamoto K. In vivo IL-10 gene delivery attenuates bleomycin-induced pulmonary fibrosis by inhibiting the production and activation of TGF-{beta} in the lung // Thorax. — 2006. Jun 29; [Epub ahead of print].
28. Muehlstedt S. G., Lyte M., Rodriguez J. L. Increased IL-10 production and HLA-DR suppression in the lungs of injured patients precede the development of nosocomial pneumonia // Shock. — 2002. — Vol. 17. — P. 443—450.
29. Grutz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression // J. Leukoc. Biol. — 2005. — Vol. 77, N 1. — P. 3—15.
30. Kirschenbaum L. A., McKevitt D., Rullan M., Reisbeck B., Fujii T., Astiz M. E. Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock // Crit. Care Med. — 2004. — Vol. 32, N 9. — P. 1904—1909.
31. Fumeaux T., Pugin J. Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock // Am. J. Respir. Crit. Care Med. — 2002. — Vol. 166. — P. 1475—1482.
32. Le Tulzo Y., Pangault C., Amiot L. et al. Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock // Am. J. Respir. Crit. Care Med. — 2004. — Vol. 169. — P. 1144—1151.
33. Tschaikowsky K., Hedwig-Geissing M., Schiele A. et al. Coincidence of pro- and anti-inflammatory responses in the early phase of severe sepsis// Crit. Care Med. — 2002. — Vol. 30. — P. 1015—1023.
34. Kim J. Y., Lee S. M. Effect of alpha-tocopherol on the expression of hepatic vascular stress genes in response to sepsis // J. Toxicol. Environ. Health A. — 2005. — Vol. 68, N 23—24. — P. 2051—2062.
35. Wolk K., Docke W. D., von Baehr V. et al. Impaired antigen presentation by human monocytes during endotoxin tolerance // Blood. — 2000. — Vol. 96. — P. 218—223.
36. Schneider C., von Aulock S., Zedler S. et al. Perioperative recombinant human granulocyte colony-stimulating factor (filgrastim) treatment prevents immunoinflammatory dysfunction associated with major surgery // Ann. Surg. — 2004. — Vol. 239. — P. 75—81.
37. Bullen T. F., Hershman M. J. Therapy for intra-abdominal adhesions // Hosp. Med. — 2004. — Vol. 65, N 6. — P. 340—342.
38. Papakostidis C., Grotz M., Giannoudis P. V. Mortality after reamed intramedullary nailing of bilateral femur fractures // Clin. Orthop. Relat. Res. — 2004. — Vol. 427. — P. 278—279.
39. Ditschkowski M., Kreuzfelder E., Rebmann V., Ferencik S., Majetschak M., Schmid E. N., Obertacke U., Hirche H., Schade U. F., Grosse-Wilde H. HLA-DR expression and soluble HLA-DR levels in septic patients after trauma // Ann. Surg. — 1999. — Vol. 229, N 2. — P. 246254.
40. Satoh A., Miura T., Satoh Ê. et al. Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis // Pancreas. — 2002. — Vol. 25. — P. 245—250.
41. Allen M. L., Peters M. J., Goldman A. et al. Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care // Crit. Care Med. — 2002. — Vol. 30. — P. 1140—1157.
42. Perry S. E., Mostafa S. M., Wenstone R. et al. Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis? // Intensive Care Med. — 2003. — Vol. 29. — P. 1245—1252.
43. Muller Kobold A. C., Tulleken J. E., Zijlstra J. G. et al. Leukocyte activation in sepsis // Intensive Care Med. — 2000. — Vol. 26. — P. 883—892.
44. Docke W. D., Randow F., Syrbe U. et al. Monocyte deactivation in septic patients // Nat. Med. — 1997. — Vol. 3. — P. 678—681.
45. Saenz J. J., Izura J. J., Manrique A. et al. Early prognosis in severe sepsis via analyzing the monocyte immunophenotype // Intensive Care Med. — 2001. — Vol. 27. — P. 970—977.
46. Monneret G., Elmenkouri N., Bohe J. et al. Analytical requirements for measuring monocytic HLA-DR by flow cytometry // Clin. Chem. — 2002. — Vol. 48. — P. 1589—1592.
47. Spittler A., Roth E. Is monocyte HLA-DR expression predictive for clinical outcome in sepsis? // Intensive Care Med. — 2003. — Vol. 29. — P. 1211—1212.
48. Oczenski W., Krenn H., Jilch R. et al. HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery // Intensive Care Med. — 2003. — Vol. 29. — 1253—1257.
49. Finck M. E., Elmenkouri N., Debard A. L. et al. Preliminary results in standardization of flow cytometry protocols for monocytic HLA-DR measurement and their application in the follow up of septic shock // Ann. Biol. Clin. — 2003. — Vol. 61. — P. 441—448.
50. Soller M., Tautenhahn A., Brune B., Zacharowski K., John S., Link H., von Knethen A. Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis // J. Leukoc. Biol. — 2006. — Vol. 79, N l. — P. 235—243.
51. Hotchkiss R. S., Coopersmith C. M., Karl I. E. Prevention of lymphocyte apoptosis — a potential treatment of sepsis? // Clin. Infect. Dis. — 2005. — Vol. 15. — P. 41.
52. Sabroe I., Dower S. K., Whyte M. K. The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis // Clin. Infect. Dis. — 2005. — Vol. 41 (suppl. 7). — P. S421—S423.
53. Hotchkiss R. S., Osmon S. B., Chang Ê. Ñ., Wagner T. H., Coopersmith C. M., Karl I. E. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways // J. Immunol. — 2005. — Vol. 174, N 8. — P. 5110—5118.
54. Hotchkiss R. S., Chang Ê. Ñ., Grayson M. H. et al. Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis // Proc. Natl. Acad. Sci. USA. — 2003. — Vol. 100. — P. 6724—6729.
55. Le Tulzo Y., Pangault C., Gacouin A. et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome // Shock. — 2002. — Vol. 18. — P. 487—494.
56. Bilbault P., Lavaux T., Lahlou A. et al. Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care // Intensive Care Med. —2004. — Vol. 30. — P. 408—415.
57-58. Harter L., Keel M., Steckholzer U. et al. Activation of mitogen- activated protein kinases during granulocyte apoptosis in patients with severe sepsis // Shock. — 2002. — Vol. 18. — P. 401—658.
59. Jilma B., Pollmacher T. Granulocyte colony-stimulating factor and cytokine release // Clin. Pharmacol. Ther. — 2000. — Vol. 68, N 2. — P. 220.
60. Lin M. T., Albertson Ò. Å. Genomic polymorphisms in sepsis // Crit. Care. Med. — 2004. — Vol. 32. — P. 569—579.
61. Sabroe I., Dower S. K.,Whyte M. K. The role of Toll-like receptors in the regulashion of neutrophil migration, activation and apoptosis // Clin. Infect. Dis. — 2005. — Vol. 15. — P. 41.
62. Flohe S., Lendemans S., Selbach Ñ. et al. Effect of granulocyte-macrophage colony-stimulating factor on the immune response of circulating monocytes after severe trauma // Crit. Care Med. — 2003. — Vol. 31. — P. 2462—2469.
63. Nierhaus A., Montag B., Timmler, Netal. Reversal of immunoparalysis by recombinant human granulocyte-macrophagecolony-stimulating factor in patients with severe sepsis // Intensive Care Med. — 2003. — Vol. 29. — P. 646—651.
64. Marshall J. C. Such stuff as dreams are made on: Mediator-directed therapy in sepsis // Nat. Rev. Drug. Discov. — 2003. — Vol. 2. — P. 39l—405.
65. Miki S., Takeyama N., Tanaka T., Nakatani T. // Crit. Care Med. — 2005. — Vol. 33, N 4. — P. 716—720.
66. Zwergal A., Quirling M., Saugel B., Huth Ê. Ñ. C/EBPbeta Blocks p65 Phosphorylation and Thereby NF-{kappa}B-Mediated Transcription in TNF-Tolerant Cells // Immunol. — 2006. — Vol. 177, N 1. — P. 665—672.
67. Parker L. C., Jones E. C., Prince L. R., Dower S. K., Whyte M. K., Sabroe I. Endotoxin tolerance induces selective alterations in neutrophil function // J. Leukoc. Biol. —2005. — Vol. 78, N 6. — P. 1301—1305.
68. Power C. P., Wang J. H., Manning B. Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2 // J. Immunol. — 2004. — Vol. 173, N 8. — P. 5229—5237.
69. Sabroe I., Dower S. K., Whyte M. K. The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis // Clin. Infect. Dis. — 2005. — Vol. 41 (suppl. 7). — P. S421—S426.
70. Hu Z., Sayeed M. M. Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury // Am. J. Physiol. Cell Physiol. — 2005. — Vol. 288, N 5. — P. C1171—C1178.
71. Scand J. C5a, interleukin-8 and tumour necrosis factor-alpha-induced changes J in granulocyte and monocyte expression of complement receptors in whole blood and on isolated leukocytes // Immunol. — 2006. — Vol. 63, N 3. — P. 208—216.
72. Furebring M., Hakansson L., Venge P., Sjolin J. Differential expression of the C5a receptor and complement receptors 1 and 3 after LPS stimulation of neutrophils and monocytes.
73. Huber-Lang M., Sarma J. V., Rittirsch D. Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans // J. Immunol. — 2005. — V ol. 174, N 2. — P. 1104—1110.
74. Wesche D. E., Lomas-Neira J. L. Leukocyte apoptosis and its significance in sepsis and shock // J. Leukoc. Biol. — 2005. — Vol. 78, 2. — P. 325—337.
75. Wesche D. E., Lomas-Neira J. L., Perl M., Chung C. S., Ayala A. Leukocyte apoptosis and its significance in sepsis and shock // J. Leukoc. Biol. — 2005 — Vol. 78, N 2. — P. 325—337.
76. Lomas-Neira J., Chung C. S., Grutkoski P. S. Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury // Cytokine. — 2005. — Vol. 31, N 3. — P. 169—179.
77. Giamarellos-Bourboulis E. J., Routsi C., Plachouras D. Early apoptosis of blood monocytes in the septic host: is it a mechanism of protection in the event of septic shock? // Crit. Care. — 2006. — Vol. 10, N 3. R76.
78. Hu M., Du Q., Vancurova I., Lin X., Miller E. J., Simms H. H. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway // Crit. Care Med. — 2005. — Vol. 33, N 11. — P. 2571—2578.
79. Wesche D. E., Lomas-Neira J. L., Perl M., Chung C. S., Ayala A. Leukocyte apoptosis and its significance in sepsis and shock // J. Leukoc. Biol. — 2005. — Vol. 78, N 2. — P. 325—337.
80. Wang F., Gao F., Jing L. Is macrophage migration inhibitory factor (MIF) the "control point" of vascular hypo-responsiveness in septic shock? // Med. Hypotheses. — 2005. — Vol. 65, N 6. — P. 1082—1087.
81. Nemeth Z. H., Csoka B., Wilmanski J., Xu D., Lu Q. Adenosine A2A Receptor Inactivation Increases Survival in Polymicrobial Sepsis // J. Immunol. — 2006. — Vol. 176, N 9. — P. 5616—5626.