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Laboratory markers for early diagnosis of neonatal sepsis


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Abstract

Sepsis in neonates still remains difficult issue for clinicians. This review observes literature data about early laboratory diagnosis of neonatal sepsis. The paper considers the latest information about well-known methods of sepsis diagnosis in neonates such as complete blood count, acute phase reactants, cytokine markers, their advantages and disadvantages, as well as statistical value based on different meta-analysis and large multicenter investigations in many countries. We notified the newest methods in sepsis diagnosis such as plasma amyloid A, DAMP molecules, cell surface markers CD64, CD11b, and inter-a inhibitor proteins. The review informs about analysis of genomic and proteomic profile, nucleic acids tools. This data considering for early and late neonatal sepsis and their statistical values: sensitivity, specificity, positive and negative predictive value.


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