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EFFECT OF GENE POLYMORPHISM OF BIOTRANSFORMATION OF OPIOID ANALGESICS AT PAIN APPRECIATION AND PHARMACOTHERAPY SAFETY


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Abstract

Background. The review presents the results of modern studies of the role of polymorphisms of the biotransformation genes of opioid analgesics in Russia and abroad for the analgesic therapy. Purpose of the study: Analysis of available publications which show the results of pharmacogenetic studies of the efficacy and safety of opioid analgesics. Material and Methods. The authors analyzed published works in Russian and foreign databases, including MedLine, PubMed, NEL elibrary.ru, Wiley Online Library, Web of Science, Oxford University Press, SAGE Premier. The period of analysis was 10 years (1996-2016). Results. It is established that polymorphism of biotransformation genes can lead to a change in the biotransformation profile of opioid analgesics in blood plasma and tissues. This is the reason for changing the pharmacological response to opioid analgesics. However, the association of most of the studied single nucleotide polymorphisms with the efficacy and safety of opioid analgesics in oncopharmacology is not clear enough. Conclusion. Translation of molecular diagnostics achievements to clinical oncopharmacology, including treatment of chronic pain, is dictated by time and necessity. Personalized approach to the choice of an opioid analgesic and its dose can provide increased safety and efficiency of treatment.


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