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Comparative analysis of the immune profile of metallurgical workers exposed to different chemical factors of production environment


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Abstract

There was performed a comparative analysis of the parameters of humoral immunity factors and topical immunity of 3000 workers of metallurgical enterprises exposed to effects of industrial mixts of different composition. Under exposure to aerosols with weak fibrogenic action there is observed simultaneous decrease of the number T-cytotoxic lymphocytes, and the increase of the number of T-helper cells, as under the influence of aerosols of complex composition (contains compounds with fibrogem action - Silicon and irritants - nitrogen dioxide, sulfur there are formed signs of hyperergic immune response with the activation of humoral compartment, T-helper cells, and the inhibition of cytotoxic lymphocytes. Aerosols with fibrogenic action have the most pronounced suppressive effect on topical immunity


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