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At aircraft manufacturing enterprises, tens of thousands of employees work, whose labor conditions in most cases do not meet sanitary and hygienic requirements. Material and methods. The work assesses the risk factors of the production environment of aircraft assemblers using instrumental research methods, there was performed a physiological assessment of severity and exhaustion levels to determine the main areas of prevention. Results. The noise and vibration were determined as prioritized harmful impact (physical) factor for workers. Vibration is perceived by all tissues of the body, but mostly by the nervous and bone system. The bone system that serves as a good conductor and resonator of vibration. The nerve endings and, above all, the receptors of the skin of the distal parts of the hands are the most sensitive to the effects of vibration. The vestibular apparatus actively reacts to vibrational stimulation. In addition, vibrations of high frequencies can have an effect on the hearing aid that is close to the effect of noise. Discussion. The results of studies indicate a high risk of the formation of occupational pathology as a result of the complex impact of physical factors and the severity of the work process. Conclusion. Studies have shown the need to introduce rational work regimes and a system of treatment and prevention activities.

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