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METHODS OF SCREENING FOR TB INFECTION IN CHILDREN AND THEIR ROLE IN THE FORMATION OF RISK GROUPS AND DIAGNOSIS OF THE DISEASE


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Abstract

In the review there are presented possibilities of the application of skin immunological tests -Mantoux test (MT) 2TE, as a specific diagnostic test - intradermal Mantoux tuberculin test with two tuberculin units; PPD-L - injectable form of purified tuberculin in standard dilution. L-tuberculin by Linnikova (MT with 2 TE PPD-L = MT) and samples with recombinant tuberculosis allergen (RTA) for the formation of high-risk groups and diagnosis of TB infection in children. Screening investigations with the use of MT have a high sensitivity (95-98%), which is an advantage of MT as the evidence base. The insufficient sensitivity of the Diaskintest® skin test (DST) preparation has been established by independent researchers (78-85% of cases of active TB are missed). The special attention was shown to have to assess the cost effectiveness of screening tests with RTA. 98% of negative results in the screening with RTA were revealed to be very expensive unreasonably. These patients failed to come in sight of health professionals, although among them there may be cases with different stages of latent TB infections requiring medical supervision by phthisiatrician. To solve the issue concerning mass application of RTA test its safety profile should be studied.


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