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SPECIES DIVERSITY AND SENSITIVITY TO ANTIBIOTICS AGAINST ORAL STREPTOCOCCI ISOLATED IN CHILDREN


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Abstract

Oral streptococci can exchange genetic material with other bacteria colonizing the same loci of the body, their resistance profiles can serve as markers of the risk of the developing resistance to certain antibiotics in closely related bacteria, in particular, Streptococcus pneumoniae. Materials and Methods To describe the species composition of oral streptococci and to detect the profile of their sensitivity to a wide range of antibiotics there were investigated oral streptococcal isolates isolated from oropharyngeal smears sown in children of various ages with acute respiratory infections not receiving antibacterial therapy for selective streptococcal medium with penicillin (Pen, 1 mg/l) or erythromycin (Ery, 2 mg/l). 253 oropharyngeal smears were studied. Results. The most frequent sowings were Pen-resistant and Ery-resistant Streptococcus mitis, found in 158 (62.5%) and 169 (66.8%) studied, respectively. Ery-resistant Streptococcus salivarius group was detected in 107 (42.3%) samples, Pen-resistant streptococcus from this group were found much less frequently in 16 (6.3%) samples. Pen and Eri-resistant isolates of Streptococcus sanguinis group were present in 69 (27.3%) and 49 (19.4%) samples respectively. All the streptococcus specimens studied were sensitive to vancomycin, linezolid and (except for one) levofloxacin; about 90% were sensitive to daptomycin, rifampicin and chloramphenicol. Sensitivity to tetracycline was lower at 57.5%. Multiple drug resistance (MDR; resistance to ≥3 groups of antibiotics) had 93 (58.1%) isolates; the most common combination of penicillin, erythromycin and tetracycline resistance was found in 53 (57%) MDR isolates. Streptococcus mitis/oralis were characterized by higher MPCs of penicillin, ampicillin and ceftriaxone, as well as the frequency of stable forms, including MDR, as compared to other streptococci. Streptococcus mitis, first S. mitis oralis group streptococcus predominate in the species structure of antibiotic-resistant oral streptocococci, among which MDR is widespread, including resistance to β-lactams.


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