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USE OF A COMBINED ACELLULAR VACCINE AGAINST PERTUSSIS INFECTION IN CHILDREN OVER FOUR YEARS OF AGE: A CROSS-SECTIONAL STUDY


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Abstract

An increase in the incidence of whooping cough has been noted in recent years in both unvaccinated and vaccinated children and adults. In Russia, recently, new possibilities of protection against pertussis infection have appeared for children over four years old and adults. Purpose: to analyze the specific immunoprophylaxis and safety of the vaccine against diphtheria, tetanus and pertussis for children over four years old in Krasnodar. Materials and methods. We examined 393 children over four years and 125 adults who were immunized with a vaccine for the prevention of diphtheria (with a reduced antigen content), tetanus, pertussis (acellular), combined, adsorbed (Adasel) at the SKIB city hospital in Krasnodar in the period from July 2018 until October 2019. The respondents had a vaccination history and did not suffer from whooping cough, according to medical records. Results. The number of people vaccinated with acellular vaccine doubled among the child population (2018 - 129; 2019 - 264) and adults (2018 - 39; 2019 - 86). General post-vaccination reactions among children amounted to 12.2% (48), weak responses prevailed - 36 (9.2%), strong responses were found in 12 people (3%). In adults, general post-vaccination responses were not observed. Local post-vaccination reactions among children amounted to 38.2% (150), weak reactions prevailed - 103 (26.2%), strong ones were found in 47 children (12%). Conclusions. During the study period, immunoprophylaxis with this vaccine doubled, showing a satisfactory safety profile. However, to reduce the incidence of whooping cough, it is advisable to examine the immunological protection and conduct revaccination with a booster dose to achieve stable post-vaccination immunity.


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